DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scw and Bmp6

DIOPT Version :9

Sequence 1:	NP_001286088.1	Gene:	scw / 46000	FlyBaseID:	FBgn0005590	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_031582.1	Gene:	Bmp6 / 12161	MGIID:	88182	Length:	510	Species:	Mus musculus

Alignment Length:	459	Identity:	128/459 - (27%)
Similarity:	200/459 - (43%)	Gaps:	108/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YQKRPLSEQMEMIDILDLGDRP----------------------------RRQAEPNLHNSASKF 67
            ::||.:  |.|::.:|.|..||                            |.:..|....||..|
Mouse    71 HEKREM--QKEILSVLGLPHRPRPLHGLQQPQPPVLPPQQQQQQQQQQTAREEPPPGRLKSAPLF 133

  Fly    68 LLEVYNEISED-----------QEPKE---------------VLHQRHKRSL-------DDDILI 99
            :|::||.:|.|           |||..               ..|..:::||       ....|.
Mouse   134 MLDLYNALSNDDEEDGASEGVGQEPGSHGGASSSQLRQPSPGAAHSLNRKSLLAPGPGGGASPLT 198

  Fly   100 SNEDRQEIASCNSILTFSSRLKPEQLDNELDMH------ITFNTNDVPVDLSLVQAMLRIYKQPS 158
            |.:|...:...:.:::|.:.:   :.|.|...|      ..||.:.:|...::..|..|:||...
Mouse   199 SAQDSAFLNDADMVMSFVNLV---EYDKEFSPHQRHHKEFKFNLSQIPEGEAVTAAEFRVYKDCV 260

  Fly   159 LVD-RRANFTVSVYRKLDNRQ--DFSYRILGSVNTTSSQRGWLEFNLTDTLRYWL----HNKGLQ 216
            :.. :...|.:|:|:.|...|  |....:|.:....:|:.|||||::|.|...|:    ||.|||
Mouse   261 VGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQ 325

  Fly   217 RRNELRISIGDS-QLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRR--- 277
                |.:...|. .::..|||||........ :||:|.:|...|:.|:..:....|..::.|
Mouse   326 ----LSVVTRDGLHVNPRAAGLVGRDGPYDK-QPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRS 385

  Fly   278 -------AGGGSPPPPPPPPVDLYRPPQ---SCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGG 332
                   .|.||..         |...:   :|::....|.|::|...:|:||||.:.|.:|.|.
Mouse   386 TQSQDVSRGSGSSD---------YNGSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGE 441

  Fly   333 CNFPLGTKMNATNHAIVQTLMHLKQP-HLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKE 396
            |:|||...||||||||||||:||..| ::|||||.||.|.||::|.:.:...:.|.||:..|.:.
Mouse   442 CSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRA 506

  Fly   397 CGCH 400
            ||||
Mouse   507 CGCH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	67/289 (23%)
scw	NP_001286088.1	TGFB	300..400	CDD:214556	48/100 (48%)
Bmp6	NP_031582.1	TGFb_propeptide	58..359	CDD:279078	69/297 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..129		4/41 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..199		8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..402		6/40 (15%)
		TGFB	409..510	CDD:214556	48/100 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.880