Protein Alignment scw and LEFTY1

DIOPT Version :10

• Sequence 1: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_066277.1
• Gene: LEFTY1 / 10637
• HGNCID: 6552
• Length: 366
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 65/296 - (21%)
• Similarity: 104/296 - (35%)
• Gaps: 85/296 - (28%)

  Fly   140 VPVDLSLVQAMLRIYKQP------------SLVDRRANFTVSVYRKLDNRQDFSYR--ILGSVNT 190
            :|.:..||||:||::::|            |....||..||...|.   |.|.|.|  ::.|...
Human   107 LPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRV---RDDGSNRTSLIDSRLV 168

  Fly   191 TSSQRGWLEFNLTDTLRYW----------LHNKGLQRRNELRISIGDSQLSTFA-----AGLVTP 240
            :..:.||..|::|:.:.:|          |....:||.:...::.|..:|..||     |||..|
Human   169 SVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEP 233

  Fly   241 QASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNF 305
            |....:|                        ||....|.|...|..|      ......|.|...
Human   234 QLELHTL------------------------DLGDYGAQGDCDPEAP------MTEGTRCCRQEM 268

  Fly   306 TVDFKELH-MHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCCVPTV 369
            .:|.:.:. ..|||:.|..|.||.|.|.|..|             ...:..|.|.|....|:.:.
Human   269 YIDLQGMKWAENWVLEPPGFLAYECVGTCRQP-------------PEALAFKWPFLGPRQCIASE 320

  Fly   370 LGAITILRYLNE------DIIDLTKYQKAVAKECGC 399
            ..::.::..:.|      .::.|...:   .::|.|
Human   321 TDSLPMIVSIKEGGRTRPQVVSLPNMR---VQKCSC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	37/142 (26%)
		TGF_beta_BMP5_like	299..400	CDD:381639	22/108 (20%)
LEFTY1	NP_066277.1	TGFb_propeptide	<106..203	CDD:480997	25/98 (26%)
		TGF_beta_LEFTY1_2	262..353	CDD:381636	21/106 (20%)