DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retn and Arid4b

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_919238.1	Gene:	Arid4b / 94246	MGIID:	2137512	Length:	1314	Species:	Mus musculus

Alignment Length:	830	Identity:	154/830 - (18%)
Similarity:	282/830 - (33%)	Gaps:	254/830 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EARHFAAN---SASNSSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKE-FLDDLFSFM 307
            ::|...||   .....|:||||....::.:. ..|::.....:..||...|:.:| ||..|:.||
Mouse   257 KSRAIPANWKTELKEDSSSSEAEEEEEEEDD-EKEKEDNSSEEEEEIEPFPEERENFLQQLYKFM 320

  Fly   308 QKRGTPINRLPIMAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQ 372
            :.||||||:.|::....|:|::|:.||...||..::.:..:|:::.:.|.:|...::|.:.::..
Mouse   321 EDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCA 385

  Fly   373 YMKYLYPYE--CEKKNLSTPAELQAAI------DGNRREGRRSSYGQYEAMH-------NQMPM- 421
            |.||||.:|  |...|:.....|...:      |...:|.:.....:.|...       |.||.
Mouse   386 YKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKE 450

  Fly   422 -TPIS---------RPSLPGGMQQMSPLALVTHAAVANNQQAQAAAAAAAAHHRLMGAPAFGQMP 476
             ||..         :|||.      |..:|:......::::.:|
Mouse   451 ETPAEDESERKENIKPSLG------SKKSLLECIPAQSDEEKEA--------------------- 488

  Fly   477 NLVKQEIESRMMEYLQLIQAKKEQGMPPVLGGNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQHHL 541
            ::.|.| |:..:|.....:|:.|:.....:.|           :::|.....:..:::.:....:
Mouse   489 HITKLE-ENENLEDKDGGRARTEEAFSTEVDG-----------EEEQARSGDETNKEEDEDDEEI 541

  Fly   542 QQQRQRSQSPDLSKHEALSAQVALWHMYHNNNSPPGS------AHTSPQQREALNLSDS------ 594
            :::.:..:..|..:.:..:.:...:..|     |||.      .....|:....::.||
Mouse   542 EEEEEEDEEEDEDEDDDDNNEEEEFECY-----PPGMKVQVRYGRGKNQKMYEASIKDSDVEGGE 601

  Fly   595 ---------------------------PPNLTNIK-REREREPTPEPVDQDDKFVDQPPPAKRVG 631
                                       ..|:..|| |::.:....:..|:|:|:..:....:|:.
Mouse   602 ALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLS 666

  Fly   632 SGLLPPGFPANFYLNPH-NMAAVAAAAGFHHPSMGH---------------QQDAASEGEPED-- 678
            .        :.|..||. .|.:....|...:....|               .:.:|.:.|.||
Mouse   667 K--------SPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDER 723

  Fly   679 ----------DYAHGEHNTTGNSS--SMHDDSEPQQMNGHHHHQTHHLDK--------------- 716
                      |.:..||:|...:.  |..:.|.|..:..:..|....:.|
Mouse   724 CTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEA 788

  Fly   717 -SDDSAIE------------NSPTT------STTTG-------------GSVGHRHSSPVSTKKK 749
             |:|:..|            ...||      .|..|             ||.|.:..   .||.|
Mouse   789 ISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKED---RTKSK 850

  Fly   750 GGAKPQSGGKDVPTEDKDASSSGKLNP-------------LETLSLLSGMQFQVA--RNGTGDNG 799
            .....::.......||::..|..|:.|             |.|.|..||.. :||  |....:|.
Mouse   851 EPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFS-EVAEKRIKLLNNS 914

  Fly   800 EPQLIVNLELNGVKYSGVLVANVP-------LSQSETR-TSSPCHAEAPTVEEEKDEEEEEEPKA 856
            :.:|..|...:.......:....|       .|.|:|. .:||.| .||    ::...||.....
Mouse   915 DERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPH-PAP----DEGAVEESLQTV 974

  Fly   857 AEEESHRSPVKQ---------ENEDVDQ------------DMEGSEVLLN 885
            ||||| .||:.:         :|:.:::            ...||..:||
Mouse   975 AEEES-CSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLN 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	32/94 (34%)
Arid4b	NP_919238.1	TUDOR	58..113	CDD:197660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..169
		RBB1NT	168..263	CDD:369729	1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..306		8/40 (20%)
		ARID_ARID4B	308..399	CDD:350647	31/90 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..577		24/181 (13%)
		CD_CSD	573..630	CDD:391946	3/56 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..678		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..888		31/181 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1215		22/87 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1256..1290
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840