DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retn and ARID4B

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001193723.1	Gene:	ARID4B / 51742	HGNCID:	15550	Length:	1312	Species:	Homo sapiens

Alignment Length:	707	Identity:	134/707 - (18%)
Similarity:	262/707 - (37%)	Gaps:	166/707 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EARHFAAN---SASNSSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKE-FLDDLFSFM 307
            ::|...||   .....|:||||....::.:. ..|::.....:..||...|:.:| ||..|:.||
Human   257 KSRTIPANWKTELKEDSSSSEAEEEEEEEDD-EKEKEDNSSEEEEEIEPFPEERENFLQQLYKFM 320

  Fly   308 QKRGTPINRLPIMAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQ 372
            :.||||||:.|::....|:|::|:.||...||..::.:..:|:::.:.|.:|...::|.:.::..
Human   321 EDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCA 385

  Fly   373 YMKYLYPY-------------------------ECEK-KNLSTPAELQAAIDGNRREGRRSSYGQ 411
            |.||||.:                         |||. |.:....|.:..|...:.|..|:...:
Human   386 YKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPR 450

  Fly   412 YE-AMHNQMPMTPISRPSLPGGMQQMSPLALVTHAAVANNQQAQAAAAAAAAHHRLMGAPAFGQM 475
            .| .:.:::......:|||  |.::....::.||    ::|:.:........:..|..
Human   451 EEKPIEDEIERKENIKPSL--GSKKNLLESIPTH----SDQEKEVNIKKPEDNENLDD------- 502

  Fly   476 PNLVKQEIESRMMEYLQL-IQAKKEQGMPPVLGGNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQH 539
                |.:..:|:.|.|.: ::|::|:..    .|:..::::....::.::...::::::......
Human   503 ----KDDDTTRVDESLNIKVEAEEEKAK----SGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDD 559

  Fly   540 HLQQQRQRSQSPDLSKHEALSAQVALWHMYHNNNSPPGSAHTSPQQREALNL------------- 591
            :.:::......|      .:..||......:..........:..:..|.|.|
Human   560 NNEEEEFECYPP------GMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEW 618

  Fly   592 -------SDSPPNLTNIK-REREREPTPEPVDQDDKFVDQPPPAKRVGSGLLPPGFPANFYLNPH 648
                   ..:..|:..|| |::.:....:..|:|:|:..:....:|:..   ||     |..||.
Human   619 IKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSK---PP-----FQTNPS 675

  Fly   649 -NMAAVAAAAGFHHPSMGHQQD----------AASEGEPEDDYAHGEHNTTGNSSSMHDDSEPQQ 702
             .|.:........:....|.:.          .|||...||             |...|:...|.
Human   676 PEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAED-------------SEQEDERGAQD 727

  Fly   703 M--NGHHHHQTHHL--DKSDDSAIENSPTTSTTTGGSVGHRH---SSPVSTKKKGGAKPQSGGKD 760
            |  ||....:..||  :::|..:.|...::|......| |..   |.|||      ..|:...||
Human   728 MDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKV-HADLVISKPVS------KSPERLRKD 785

  Fly   761 VP--TEDKDASSSGKLNPLETLSLLSGMQFQVARNGTGDNGEPQLIVNLELNGVKYSGVLVANVP 823
            :.  :||.|.....          ::..:..|.::.|..:.:||         :|.......|
Human   786 IEVLSEDTDYEEDE----------VTKKRKDVKKDTTDKSSKPQ---------IKRGKRRYCN-- 829

  Fly   824 LSQSETRTSSPCHAEAPTVEEE----------KDEEEEEEPKAAEEESHRSPVKQEN 870
             ::...:|.||...|.....:|          ..:|:|||.||     ..:|.|:.|
Human   830 -TEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKA-----KMTPTKKYN 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	33/118 (28%)
ARID4B	NP_001193723.1	TUDOR	58..113	CDD:197660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..166
		RBB1NT	170..262	CDD:285392	1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..306		8/40 (20%)
		ARID	311..394	CDD:198082	28/82 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..577		16/145 (11%)
		Antigenic epitope	465..473		4/9 (44%)
		Tudor-knot	571..624	CDD:288553	6/58 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..680		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..894		48/220 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..1212
		Antigenic epitope	1130..1137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1252..1288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840