DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retn and arid3a

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001011106.1	Gene:	arid3a / 496519	XenbaseID:	XB-GENE-945264	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	399	Identity:	155/399 - (38%)
Similarity:	202/399 - (50%)	Gaps:	112/399 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 SPTAAPSGKEARHFAANSASNSSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKEFLDD 302
            :|.|.|:.:..      .|..:..........|.:..|::|||||   ||||::.||||||||||
Frog   166 NPQAFPTQRSV------GAERAGLPHTGHPQLQDHGDWTYEEQFK---QLYELDGDPKRKEFLDD 221

  Fly   303 LFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAF 367
            |||||||||||:||:|||||.|||||.||.||..:||||:|||||||:||.|||:||:|||||||
Frog   222 LFSFMQKRGTPVNRIPIMAKQVLDLYMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAF 286

  Fly   368 TLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNRREGRRSSYGQYEAMHN--------QMPMTPI 424
            |||||||||||||||||:.||.|.|||||||.|||||||.|:|.....::        ..|...:
Frog   287 TLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFTYSPSGAPSMLSSPKLQV 351

  Fly   425 SRPSLPG---------GMQQMS---------------PLALVTHAAVANNQQAQAAAAAAAAHHR 465
            |..||.|         .||::.               |::|..|:.||    ||.||.|||
Frog   352 SALSLGGVATNGSSLSSMQKIKKEEDSPISLTVPPRIPVSLAGHSMVA----AQVAAQAAA---- 408

  Fly   466 LMGAPAFGQMPNLVKQEIESRMMEYLQLIQAKKEQGMPPVLGGNHPHQQQHSQQQQQQQHHHQQQ 530
                                     |:.::.|.|.|.||               :::.....::|
Frog   409 -------------------------LEQLREKLESGEPP---------------EKKMALGTEEQ 433

  Fly   531 QQQQSQQQHHLQQQRQRSQSPDLSKHEALSAQVALWHMYHNNNSPPGSAHTSPQQREALNLSDSP 595
            |:.|...||:|.               |::||:.:  ....|:...|      :|..|:||:.:.
Frog   434 QRLQRAIQHNLL---------------AMTAQLPM--NIRINSQAEG------RQDSAVNLTTNG 475

  Fly   596 PNLTNIKRE 604
            .|..::..|
Frog   476 TNSISMSVE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	78/91 (86%)
arid3a	NP_001011106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..172		2/5 (40%)
		ARID_ARID3A	193..325	CDD:350642	104/134 (78%)
		Important for nuclear localization. /evidence=ECO:0000250	408..450		14/100 (14%)
		Homodimerization. /evidence=ECO:0000250	452..473		6/28 (21%)
		Important for cytoplasmic localization. /evidence=ECO:0000250	497..504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001099
OrthoInspector	1	1.000	-	-		otm48042
Panther	1	1.100	-	-	O	PTHR15348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040