DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retn and arid-1

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001300004.1	Gene:	arid-1 / 4363100	WormBaseID:	WBGene00044689	Length:	1648	Species:	Caenorhabditis elegans

Alignment Length:	761	Identity:	149/761 - (19%)
Similarity:	228/761 - (29%)	Gaps:	267/761 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 QFSFASPTAAPSGKE---------ARHFAANSASNSSTSSEASNSSQQNNGWSF----------- 277
            ::|||..||....|.         |..||.:.|.|...:....:..:    |.|
Worm   556 EYSFADVTAMTEKKPVEMRRKFKLAWRFATDYAQNRLDARSIRSILE----WKFIRPSSRRLKIT 616

  Fly   278 --EEQFKQVRQLYEINDD----PKRKEFLDD-----------------LFSFMQKRGTPINRLPI 319
              ..|.....:..|.:||    |...::..|                 |..|.....:.|:..|.
Worm   617 PIPVQAPSPNRCGEDHDDLVSTPNESDYDSDATIKNVDAETKDLFVAMLVQFHDAHNSVIDTNPT 681

  Fly   320 MAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYECEK 384
            :....:|||.||.|....||...|....||.:..|.| :|:: |.|...|:|.:..:|..|....
Worm   682 IQGHEVDLYYLYELAKKTGGPKKVYAANLWSDYAKKL-VPAA-TDAEEELKTIFKNFLESYLAIN 744

  Fly   385 KNLSTP-------AELQAAIDGNRREGRRSSYGQYEAMHNQMPMTPISRPSLPGGMQQMSPLALV 442
            ..||.|       .|.:..:.|...|.|:.   :.:|:.:|: .||   |:.||
Worm   745 TKLSWPMESLQPRTERKVVLPGQYSESRKK---RTQAIMSQV-QTP---PTAPG----------- 791

  Fly   443 THAAVANNQQAQAAAAAAAAHHRLMGAPAFGQMPNLVKQEIESRMMEYLQLIQAKKEQGMPPVLG 507
                  ::::.:..:......                |:::.|   |.:||.:..::........
Worm   792 ------SSKKGRVGSGGTRGR----------------KRKVSS---ESVQLKKRNRKSSSRATTA 831

  Fly   508 GNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQHHLQQQRQRSQSP-DLSKHEALSAQVALWHMYHN 571
            ...|.:.:.|.|:.|...                    ..:..| |::.||.|..:.|....|..
Worm   832 SPGPSEDRFSFQRPQDSD--------------------DVTDVPDDMTDHEDLLPEAATRKKYER 876

  Fly   572 NNSPPGSAHTSPQQREALNLSD---SPPNLTNIKREREREPT----------------PEPVDQD 617
            .:..||....|.::.:...:|.   :||     |:.|.|:.|                |...|..
Worm   877 KSQTPGRRSLSSRRDDTTPVSSMAAAPP-----KKGRPRKNTTVTTPVLSVPKSEGRGPRKEDTT 936

  Fly   618 DKFVDQPPPAKRVGSGLLPPGFPANFYLNPHNMAAVAAAAGFHHPSMGHQQDAASEGEPEDDYAH 682
            .|||     ...|.|.:|.......||                    |.:...|:..|...|..
Worm   937 TKFV-----RANVLSHILSGQKLRAFY--------------------GDEWFRANAIEDATDCT- 975

  Fly   683 GEHNTTGNSSSMHDDSEPQQMNGHHHHQTHHLDKSDDSAIENSPTTSTTTGGSVGHRHSSPVSTK 747
                          |.....|..|....|....:...|||::..                  ...
Worm   976 --------------DEIMDIMLAHQDFFTPDTPRLSPSAIQDLD------------------KVL 1008

  Fly   748 KKGGAKPQSGG------------KDVPTEDKDASSSGKLNPL--------ETLSLLSGMQFQVAR 792
            ||..||....|            |.:.|.:....:.|:...|        |||:|:.    :..|
Worm  1009 KKIRAKTHYTGWNQRYDEFMKLEKLMVTVEDQMIARGRFRHLPRGRELKAETLALVE----KHFR 1069

  Fly   793 NGTGDNGEPQLIVNLELNGVKYSGVLVANVPLSQSETRT---------------SSPCHAEAPTV 842
            ....|:|.|:.:...         :.:|...||.||.|.               ..|..:.|..|
Worm  1070 ADDEDDGVPKTLAFY---------LKIAQEALSLSEKRAVADDDESSDSDTDFEQKPDTSAAAAV 1125

  Fly   843 EEEKDE-EEEEEPKA--------AEEESHRSPVKQEN---EDVDQD 876
            ...|.| |||||.|.        ||||     ||.|:   |.|||:
Worm  1126 NGGKSESEEEEEEKTVVMGGDEEAEEE-----VKSEDVLVESVDQE 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	26/108 (24%)
arid-1	NP_001300004.1	ARID	658..740	CDD:198082	23/83 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930