DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retn and arid4a

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_005158686.1	Gene:	arid4a / 327404	ZFINID:	ZDB-GENE-050809-105	Length:	1332	Species:	Danio rerio

Alignment Length:	745	Identity:	151/745 - (20%)
Similarity:	265/745 - (35%)	Gaps:	234/745 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 STSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDP---KRKEFLDDLFSFMQKRGTPINRLPIMA 321
            |:||:..:..:...|...||:.|: .:..|.:|:|   :|..||..|:.||:.||||||:.|::.
Zfish   273 SSSSDEDDEDEDGEGKEGEEEEKE-PEPEEPDDEPDPEERDHFLQQLYKFMEDRGTPINKPPVLG 336

  Fly   322 KSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYECEKKN 386
            ...|:|::|:.||...||..::.:..:|::|...|.:|...::|::.::|.|.||||.:|
Zfish   337 YKDLNLFKLFRLVHIHGGCDNIESGSIWKQIYMDLGIPVLNSAASYNVKTAYRKYLYGFE----- 396

  Fly   387 LSTPAELQAAIDGNRREGRRSSYGQYEAMHNQMPMTPISRPSLPGGMQQMSPLALVTHAAVANNQ 451
                            |..||:..|:..:|:..|     ||.:...:|.:..   ||..:..|::
Zfish   397 ----------------EYCRSAQIQFRTVHHNEP-----RPDVQPEVQSIKS---VTKESENNDE 437

  Fly   452 QAQAAAA---------AAAA-------------------HHRLMGAPAFGQMPNLVKQEI-ESRM 487
            ..|...|         ||.|                   ..|.:..|...:|..|.:::| |.:.
Zfish   438 MMQQVTAEPGTSEDKPAADADESDAESEKGRKDVCSPRGRRRCLTTPVKVEMEPLKQEKIKEEKK 502

  Fly   488 MEYLQLI-----QAKKEQGMPPVLGGNHPHQQQHS--------------QQQQQQQHHHQQQQQQ 533
            .|..|.:     :..||:....:.|.....:.:.|              :|....:...::::..
Zfish   503 KEDTQSVGENSGEEPKEKSDGEIPGKRRSRRHEESDKDSEEDDDDNDDEEQDDDDEDDEEEEEDD 567

  Fly   534 QSQQQHHLQQQRQRSQSP-------DLSKHEALSAQVALWH-------MYHNNNSPPGSAHTSPQ 584
            ..:::.:.::.|.|.:..       :.|:|.....:|.:.:       :|..|     ..:|...
Zfish   568 DDEEEDYFERSRLRERDEREEGDGCEDSEHSLAGTKVRVKYGKGKTQKIYEAN-----IKNTETD 627

  Fly   585 QREALNL---------------SDS---PPNLTNIKREREREPTPEPVDQDDKFVDQP------- 624
            ..|.|.|               :|.   |.:....|::::::...:..::.:|..|:.
Zfish   628 DGEVLYLVHYYGWNVRYDEWVKADRIIWPVDKGGTKKKQKKKVKNKEDEEKEKEEDKTKVVVRRG 692

  Fly   625 -PPAKRVGSGLLPPGFPANFYLNPHNMAAVAAAAGFHHPSMGHQQDAAS----EGEPED------ 678
             ||.|..     |||          ......::.|..........||::    :|.|..
Zfish   693 RPPLKST-----PPG----------TSRKTPSSEGRSSSKNSRPTDASALPNGDGTPRRRTRRTS 742

  Fly   679 ---DYAHGEHNTTGNSSSMHDDSEPQQMNGHHHHQTHHLDK---SDDSAIENSPTTSTTTGGSVG 737
               |...|. |.:||||   ||||.::........|...|.   :...|.::.|..|||
Zfish   743 GMYDSDRGS-NDSGNSS---DDSEGEKSPEKKQEWTERTDPPPIAKQEAADDLPEESTT------ 797

  Fly   738 HRHSSPVSTKKKGGAKPQSGGKDVPTEDKDASSSGKLNPLETLSLLSGMQFQVARNGTGDNGEPQ 802
               ..|..|:.:..:.||.......:|.|....| .:.|.|:                 |.|.|:
Zfish   798 ---QEPAQTEPELPSSPQEMPNFNESESKPEEDS-SMPPTES-----------------DVGSPK 841

  Fly   803 LIVNLELNGVKYSGVLVANVPLSQ---SETRTSSPC----HAEAPTVEEEKDEEEEEEP---KAA 857
                           :.|..|..:   |||.|.:|.    |||.        ||....|   |.:
Zfish   842 ---------------MTAKKPRLKEPGSETPTQTPAAANHHAET--------EEPSTPPRPVKKS 883

  Fly   858 EEESHRSPVKQ-------------ENEDVD 874
            :|..|.|||::             ..||:|
Zfish   884 QETPHSSPVERIKLVETAGSDTDSATEDID 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	33/94 (35%)
arid4a	XP_005158686.1	TUDOR	58..113	CDD:295375
		RBB1NT	171..260	CDD:285392
		ARID	311..396	CDD:198082	31/84 (37%)
		Tudor-knot	601..654	CDD:288553	8/57 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840