DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retn and Arid4a

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_038968184.1	Gene:	Arid4a / 314205	RGDID:	1307442	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	768	Identity:	156/768 - (20%)
Similarity:	279/768 - (36%)	Gaps:	224/768 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 SSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDP-KRKEFLDDLFSFMQKRGTPINRLPIMAK 322
            ||:|.:....::::.....:|..|:..:|.|...|| :|..||..|:.||:.||||||:.|::..
  Rat   293 SSSSDDEECPAEEHEEEKEKEAKKEEEELPEEELDPEERDNFLQQLYKFMEDRGTPINKAPVLGY 357

  Fly   323 SVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYE--CEKK 385
            ..|:|::|:.||..:||...:.:..:|::|...|.:|...::|::.::|.|.||||.:|  |...
  Rat   358 KDLNLFKLFRLVYHQGGCDSIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSA 422

  Fly   386 NLSTPAELQAAIDGNRREGRRSSYGQYEAMHNQMPMTPISRPSLPGGMQ------QMSPLALVTH 444
            |:                       |:..:|:..|.....:......|.      |..||..|..
  Rat   423 NI-----------------------QFRTIHHHEPKVKEEKKDFEESMDEALKVAQEMPLMDVKS 464

  Fly   445 AAVANNQQAQAAAAAAAAHHRLMGAPAFGQMPNLVKQEIESRMMEYLQL---------------I 494
            ....|......:...........|.....:..|.:|:|:|...:|...:               |
  Rat   465 EPEENIDSNSESDREDTELKSPRGRRKIVREANCIKKELEEEKIEDKLIGDDIDNKDADDDDYDI 529

  Fly   495 QAKKEQGMPPVLG-GNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQHHLQQQ-------------- 544
            ..|||..:  :|| ...|..::...:||:......::::::||::...:.:
  Rat   530 AEKKETEL--LLGRKTTPKHKEKKIKQQEDSERDSEEEEEKSQEREETESRCDSEGEDDEDDTEP 592

  Fly   545 ------------RQRSQ--------SPDLSKHEAL----------------SAQVALWHMYHNNN 573
                        |.::|        |.::...|.|                .|...:|.:  :..
  Rat   593 CLTGTKVKVKYGRGKTQKIYEASIKSTEMDDGEVLYLVHYYGWNVRYDEWVKADRIIWPL--DKG 655

  Fly   574 SPPGSAHTSPQQREALNLSDSPPNLTNIKREREREPTPEPVDQDDKFVDQPPPAKRVGSGLLPPG 638
            .|     ...|:::..|..||.   .:.||:.||:.:..         .:||         |...
  Rat   656 GP-----KKKQKKKVKNKEDSE---KDEKRDEERQKSKR---------GRPP---------LKST 694

  Fly   639 FPANFYLNPHNMAAVAAAAGFHHPSMGHQQDAASEGEPEDDYAHGEHNTTG------------NS 691
            |.:|.   |::::..:       .|.|.....:|:.|.||..   |.::..            .|
  Rat   695 FSSNM---PYSLSKTS-------NSEGKSDSCSSDSEAEDQL---EKSSVSEELSPDIKEELEKS 746

  Fly   692 SSMHDDSEPQQMNGHHHHQTHHLDKSDD--SAIENSPTTSTTTGGS------VGHRHSSPVSTKK 748
            .::|||...::     :.:|.|:...:|  .|..:.|.| ...|.|      .|.:.......||
  Rat   747 ENVHDDKLAEE-----NPKTVHISNENDRTQAQPSEPLT-VEAGDSDQIVHIFGDKVEQAEELKK 805

  Fly   749 KGGAKPQSGGKDVPTED-------------KDASSS--GKLNPLETLSL----LSGMQFQV---- 790
            :....|::.|:...|:|             ::|.|.  |..:.||..||    .|..:..|
  Rat   806 QVEKSPKAKGRRNKTKDLSLELIKISPFSQEEAGSEARGDTHSLEFSSLECKNFSSTEDDVDQYE 870

  Fly   791 -----ARNGTGDNGEPQLIVNLELNGVKYSGVLVANVPLSQSETRTSSPC------HAE------ 838
                 .|...|.: .|:..:.|| |||:.:      ..|||..:..|:..      |.|
  Rat   871 KEKKLKRKILGQH-SPEKKLRLE-NGVEMT------TGLSQERSDDSAVAEGVKGVHVEQRFEAE 927

  Fly   839 ---APTVEEEKDEEEEE----EPKAAEEESHRSPVKQENEDVDQDMEGSEVLL 884
               .|::..|.|:..:|    :|.:..||...:|:|:| ||| ..:.|.|.|:
  Rat   928 GEGMPSLIAEPDQGIQEPTGVKPDSPAEEPAHTPLKEE-EDV-MPLIGPETLV 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	34/94 (36%)
Arid4a	XP_038968184.1	Tudor_ARID4A_rpt1	23..80	CDD:410530
		Tudor_SF	81..137	CDD:413384
		RBB1NT	189..281	CDD:400474
		ARID	331..416	CDD:355778	31/84 (37%)
		CBD_RBP1_like	597..655	CDD:350843	7/59 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810