DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retn and Arid4a

DIOPT Version :9

Sequence 1:	NP_788434.1	Gene:	retn / 45976	FlyBaseID:	FBgn0004795	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_036013289.1	Gene:	Arid4a / 238247	MGIID:	2444354	Length:	1283	Species:	Mus musculus

Alignment Length:	760	Identity:	142/760 - (18%)
Similarity:	264/760 - (34%)	Gaps:	207/760 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 SSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDP-KRKEFLDDLFSFMQKRGTPINRLPIMAK 322
            ||:|.:....::::.....:|..|:..:|.|...|| :|..||..|:.||:.||||||:.|::..
Mouse   274 SSSSDDEECPAEEHEEEKEKEAKKEEEELPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGY 338

  Fly   323 SVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYE--CEKK 385
            ..|:|::|:.||..:||..::.:..:|::|...|.:|...::|::.::|.|.||||.:|  |...
Mouse   339 KDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSA 403

  Fly   386 NLSTPAELQAAIDGNRREGRRSSYGQYEAMHNQMPMTPISRPSLPGGMQQM------SPLALVTH 444
            |:                       |:..:|:..|.....:......|.:.      .||..|..
Mouse   404 NI-----------------------QFRTIHHHEPKVKEEKKDFEDSMDEALKEAPEMPLLDVKS 445

  Fly   445 AAVANNQQAQAAAAAAAAHHRLMGAPAFGQMPNLVKQEIESRMME--YLQLIQAKKEQG-----M 502
            ....|......:...........|.....:..|.:|:|||...:|  :|:.....|:.|     .
Mouse   446 EPEENTDSNSESDREDTELKSPRGRRKIVRDANCIKKEIEEEKIEDKFLRDDLENKDAGDDDDDG 510

  Fly   503 PPVLGGNH---------PHQQQHSQQQQQQQHHHQQQQQQQSQQQHHLQQQ-------------- 544
            .|.....|         |..::...::.:.......:::::||::...:.:
Mouse   511 DPAAKREHELLFGRKSTPKNKEKKIKKPEDSERDSDEEEEKSQEREETESRCDSEGEDEEDDTEP 575

  Fly   545 ------------RQRSQ--------SPDLSKHEAL----------------SAQVALWHMYHNNN 573
                        |.::|        |.::...|.|                .|...:|.:...
Mouse   576 CLTGTKVKVKYGRGKTQKIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKADRIIWPLDKG-- 638

  Fly   574 SPPGSAHTSPQQREALNLSDSPPNLTNIKREREREPTPEPVDQDDKFVDQPPPAKRVGSGLLPPG 638
                    .|::::...:...|..|.:........|.|...:::|...|:....:|..|....|.
Mouse   639 --------GPKKKQKKKVKCQPCLLAHCTLGHAFCPVPAVENKEDSEKDEKRDEERQKSKRGRPP 695

  Fly   639 FPANFYLN-PHNMAAVAAAAGFHHPSMGHQQDAASEGEPEDDYAHGEHNTTGNSSSMHDDSEPQQ 702
            ..:.|..| |::::..:.:.|        :.|:.|.....||..   ..::|......|..|..:
Mouse   696 LKSTFSPNMPYSLSKTSNSEG--------KSDSCSSDSEADDQL---EKSSGGEDLSPDVKEELE 749

  Fly   703 MNGHHHH--------QTHHLDKSDD-SAIENSPTTSTTTGGS------VGHRHSSPVSTKKKGGA 752
            .|.:.|.        :..|:.|.:| :..:.|.|.:...|.|      .|.:.......||:...
Mouse   750 KNENAHDDKLDEENPKIVHISKENDRTQAQPSDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEK 814

  Fly   753 KPQSGGKDVPTEDKDASSSGKLNPLETLSLLSGMQFQVARNGTGDNGEPQLIVNLELNGVKYSGV 817
            .|:..|:...|:|                                       ::|||  :|.|
Mouse   815 SPKGKGRRSKTKD---------------------------------------LSLEL--IKIS-- 836

  Fly   818 LVANVPLSQSETRTSSPCHAEAPTVEEEKDE-------EEEEEPKAAEEESHRSPVKQENED--- 872
                 |..|.|  ..|..|.:..::|....|       |::.:|...|::..|..:.|::.:
Mouse   837 -----PFGQEE--AGSEAHGDVHSLEFSSLECKNFSSTEDDIDPYEKEKKLKRKILGQQSPEKKL 894

  Fly   873 -VDQDME----GSEVLLNGGASAVGGAGAGV-------GVGVPLL 905
             :|..||    .|:...:.||.|.|..||.|       |.|:|.|
Mouse   895 RLDNGMEMTTGVSQERSDDGAGAEGMKGAHVEQHFETEGEGMPSL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retn	NP_788434.1	BRIGHT	294..386	CDD:128777	34/94 (36%)
Arid4a	XP_036013289.1	Tudor_ARID4A_rpt1	4..61	CDD:410530
		Tudor_SF	62..118	CDD:413384
		RBB1NT	170..262	CDD:400474
		ARID_ARID4A	312..397	CDD:350646	31/84 (37%)
		CBD_RBP1_like	580..638	CDD:350843	7/57 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840