DRSC/TRiP Functional Genomics Resources

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Protein Alignment retn and ARID3A

DIOPT Version :10

Sequence 1:NP_788434.1 Gene:retn / 45976 FlyBaseID:FBgn0004795 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_005215.1 Gene:ARID3A / 1820 HGNCID:3031 Length:593 Species:Homo sapiens


Alignment Length:667 Identity:204/667 - (30%)
Similarity:259/667 - (38%) Gaps:245/667 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 DEMRDCDSVDGEHHQLSAKAAI---AARLSHTVSGGGGSFASPEPQTELPLSHHHQLPPNHPLNA 98
            ||.|:.:|...:..|::|.||:   ||.|.|..|.||.....|..:.|   ....:..|..|   
Human    44 DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEE---DAAREGTPGSP--- 102

  Fly    99 LGSFMGIGGLHSIPNLQH-----SDVLEKLKMQVRDMKVGL------MEQDY------------- 139
                   |.....|..:|     ||...|.|.:..:|:..|      .|:||             
Human   103 -------GRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLG 160

  Fly   140 ----AAAAHAAAFGANMLPTTISSGFPLPHNSVAFGHVTSSPSGGNGSSYNGGTTPTNSSNSNAT 200
                |:....|.|.....|.....|..:|.                  ...|...|         
Human   161 PPGPASLGTTALFPRKAQPPQAFRGDGVPR------------------VLGGQERP--------- 198

  Fly   201 TNGGGTAGPGGTGGSGGGGGGGGGGGGGVGGHQFSFASPTAAPSGKEARHFAANSASNSSTSSEA 265
              |.|.|.|||.                      :..:|...|                      
Human   199 --GPGPAHPGGA----------------------AHVAPQLQP---------------------- 217

  Fly   266 SNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYEL 330
                ..:..|::|||||   ||||::.|||||||||||||||||||||:||:|||||.||||:.|
Human   218 ----PDHGDWTYEEQFK---QLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFML 275

  Fly   331 YNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSTPAELQA 395
            |.||..:||||:|||||||:||.|||:||:||||||||||||||||||||||||:.||.|.||||
Human   276 YVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQA 340

  Fly   396 AIDGNRREGRRSSYG----QYE--AMHNQM--PMTPISRPSL----------------------- 429
            |||.|||||||.|:|    .|.  ..|..:  |..|:|...|                       
Human   341 AIDSNRREGRRQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAI 405

  Fly   430 ----PGGMQQMSPLALVTHAAVANNQQAQAAAAAAAAHHRLMGAPAFGQMPNLVKQEIESRMMEY 490
                ||.:    |::|..|..||    |||||..|||....:.|.|..                 
Human   406 PITVPGRL----PVSLAGHPVVA----AQAAAVQAAAAQAAVAAQAAA----------------- 445

  Fly   491 LQLIQAKKEQGMPPVLGGNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQHHLQQQRQRSQSPDLSK 555
            |:.::.|.|...||             :::.......||:..|::.||:.|              
Human   446 LEQLREKLESAEPP-------------EKKMALVADEQQRLMQRALQQNFL-------------- 483

  Fly   556 HEALSAQVALWHMYHNNNSPPGSAHTSPQQREALNLSDSPPNLTNIKRERE-------------- 606
              |::||:            |.|...:.|..|  :..||..|||.......              
Human   484 --AMAAQL------------PMSIRINSQASE--SRQDSAVNLTGTNGSNSISMSVEINGIMYTG 532

  Fly   607 ----REPTPEPVDQDDK 619
                :.|.|.|....:|
Human   533 VLFAQPPAPTPTSAPNK 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
retnNP_788434.1 ARID_Dri-like 277..401 CDD:350645 97/123 (79%)
ARID3ANP_005215.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..222 47/267 (18%)
Acidic 119..156 9/36 (25%)
ARID_ARID3A 219..351 CDD:350642 103/134 (77%)
Important for nuclear localization. /evidence=ECO:0000250 445..488 12/88 (14%)
Homodimerization 490..513 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..516 7/20 (35%)
Important for cytoplasmic localization. /evidence=ECO:0000250 537..557 4/13 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..593 4/11 (36%)

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