DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and Prkcq

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001263650.1	Gene:	Prkcq / 85420	RGDID:	620968	Length:	707	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	109/365 - (29%)
Similarity:	157/365 - (43%)	Gaps:	73/365 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 WHRPLTNSIFNSHFKETSKN------------DLYRIDHLVAKGAFGVVFKVSSKSDISQCYALK 189
            |..||..:...:...|...|            |.:.:..::.||:||.||....|. ..|.:|:|
  Rat   346 WESPLDGADKTAQPPEPEVNLQRASLQLKLKIDDFILHKMLGKGSFGKVFLAEFKR-TKQFFAIK 409

  Fly   190 VLKKSKLIEDNSVRQIKDEADIQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKIT--- 251
            .|||..::.|:.|.....|..:..:...|||:......:|.:.||..:.||:..|:|...|.
  Rat   410 ALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCH 474

  Fly   252 HFSIDLVRLYIGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSKWLKLG-ANTRTM 315
            .|.:.....|..||.|.|.|||:.||:|||.|.:||||....|||:.|||:.|...|| |.|.|.
  Rat   475 KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTF 539

  Fly   316 CGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIA 380
            |||..|:|||||.|:.|.|:||||:.||:..:||..:||            ...:|......||.
  Rat   540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSP------------FHGQDEEELFHSIR 592

  Fly   381 QINGCLQDSDGDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQRIRSVMALQRIAIYKDYN----- 440
            ..|           .|.|   :.|..|.:|:|.||...||.:|:.....:::..::::.|
  Rat   593 MDN-----------PFYP---RWLEREAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELE 643

  Fly   441 -------------------------LSSKQLLSLSPREII 455
                                     ||.|..||.:.|.:|
  Rat   644 RKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRALI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	95/275 (35%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	78/190 (41%)
Prkcq	NP_001263650.1	C1_1	160..212	CDD:278556
		C1_1	232..284	CDD:278556
		STKc_nPKC_theta	374..704	CDD:270770	104/337 (31%)
		S_TKc	380..634	CDD:214567	95/280 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910