DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6KL and YPK3

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_009584.1	Gene:	YPK3 / 852316	SGDID:	S000000232	Length:	525	Species:	Saccharomyces cerevisiae

Alignment Length:	371	Identity:	112/371 - (30%)
Similarity:	167/371 - (45%)	Gaps:	94/371 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 RHRNKATRK--SLT-------SLHGSRRGKTQWHR-PLT-NSIFNSHFKETSKNDLYRIDH---- 163
            |.|:.|..|  .||       |:.||...:|..:| .:| ..|.:|:..|   |:|.|..|
Yeast    69 RRRSSAYSKFPILTPPNTRRFSITGSDAMRTNTNRLSITPQDIISSNIGE---NELSRNLHDFKP 130

  Fly   164 --LVAKGAFGVVFKVSSKSDISQCYALKVLKKSKLI----EDNSVRQIKDEAD------------ 210
              ::.:||:|.|..|.. .:.|:.||:|.|:|::::    ..:|.|:.:|:.|
Yeast   131 VRVLGQGAYGKVLLVKD-VNTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGNNNDNDDGLSK 194

  Fly   211 -----------IQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKI-THFSID--LVRLY 261
                       :.::  .||.|||....:.:...|::|.:|:|.||||..: .|.::|  .|..|
Yeast   195 RLERTFAERSILSEI--EHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSFY 257

  Fly   262 IGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSKWLKLGANTR------------- 313
            ..||:.||.|||..|::|||.||||.||.::.|:.|||||||   |..||..
Yeast   258 AAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLS---KKSANDSAVDEEDPENVNAL 319

  Fly   314 -TMCGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAP 377
             ::.||.:|.|||||.|:.|....||::||.:...||..|.|...                ||..
Yeast   320 YSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTG----------------SNHK 368

  Fly   378 SIAQINGCLQDSDGDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQR 423
            .|  ||...|:..|....|      :|:...:|:|..||..|..:|
Yeast   369 VI--INKIQQNKQGPKIPF------YLSEGMKDILNALLKKETAKR 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	95/315 (30%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	77/230 (33%)
YPK3	NP_009584.1	STKc_AGC	134..406	CDD:270693	92/301 (31%)
YPK3	NP_009584.1	S_TK_X	445..516	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900