DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and Rps6kb1

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_114191.1	Gene:	Rps6kb1 / 83840	RGDID:	620683	Length:	525	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	120/362 - (33%)
Similarity:	173/362 - (47%)	Gaps:	77/362 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 ETSKN--------DLYRIDHLVAKGAFGVVFKVS--SKSDISQCYALKVLKKSKLIEDNSVRQIK 206
            |||.|        :.:.:..::.||.:|.||:|.  :.::..:.:|:|||||:.:     ||..|
  Rat    76 ETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMI-----VRNAK 135

  Fly   207 DEAD-------IQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKITH---FSIDLVRLY 261
            |.|.       :::|  .|||||..|..:|....|:::.||:..||||.::..   |..|....|
  Rat   136 DTAHTKAERNILEEV--KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 198

  Fly   262 IGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSK-WLKLGANTRTMCGTFKYMAPE 325
            :.||::||..||..||||||.|||||:|..|.|:|||||||.| .:..|..|.|.|||.:|||||
  Rat   199 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 263

  Fly   326 ILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIAQINGCLQDSD 390
            ||....:..|||||:||.:...|||               ...|..|.:...:|.:|..|..:
  Rat   264 ILMRSGHNRAVDWWSLGALMYDMLT---------------GAPPFTGENRKKTIDKILKCKLN-- 311

  Fly   391 GDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQRIRS----VMALQRIAIYKDYNLSSKQLLSLSP 451
                  ||   .:||.|.||:|:|||......|:.:    ...:|....::..|.
  Rat   312 ------LP---PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINW---------- 357

  Fly   452 REIIARDGIRIY-------ED-RHFD-QLTNQCAIDA 479
            .|::||...|.:       || ..|| :.|.|..:|:
  Rat   358 EELLARKVERPFKPLLQSEEDVSQFDSKFTRQTPVDS 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	103/288 (36%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	86/199 (43%)
Rps6kb1	NP_114191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		TOS motif	28..32
		S_TKc	91..352	CDD:214567	104/293 (35%)
		STKc_p70S6K	94..416	CDD:270736	116/344 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		5/15 (33%)
		Autoinhibitory domain	424..525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810