DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and RPS6KB2

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_003943.2	Gene:	RPS6KB2 / 6199	HGNCID:	10437	Length:	482	Species:	Homo sapiens

Alignment Length:	375	Identity:	126/375 - (33%)
Similarity:	175/375 - (46%)	Gaps:	82/375 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 ETSKN-----------DLYRIDHLVAKGAFGVVFKVS--SKSDISQCYALKVLKKSKLIEDNSVR 203
            |||.|           :|.|:   :.||.:|.||:|.  ..:::.:.||:|||:|:|:     ||
Human    52 ETSVNVGPERIGPHCFELLRV---LGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKI-----VR 108

  Fly   204 QIKDEAD-------IQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKITH---FSIDLV 258
            ..||.|.       ::.|  .|||||:....:|....|:::.|.:..||||:.:..   |..|..
Human   109 NAKDTAHTRAERNILESV--KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTA 171

  Fly   259 RLYIGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSK-WLKLGANTRTMCGTFKYM 322
            ..|:.||.|||..||:.||||||.|||||:|:.|.|||||||||.| .:..||.|.|.|||.:||
Human   172 CFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYM 236

  Fly   323 APEILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIAQINGCLQ 387
            |||||....:..|||||:||.:...|||...|....:..:..:.:              |.|.|.
Human   237 APEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKI--------------IRGKLA 287

  Fly   388 DSDGDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQRI----RSVMALQRIAIYKDYNLSSKQLLS 448
                     ||   .:||.:.||:::|.|...|.|||    .....:||...::..|........
Human   288 ---------LP---PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340

  Fly   449 LSPREIIARDGIRIYED-RHFD-QLTNQCAID-------------AFLDF 483
            :.|.   .|..::..|| ..|| :.|.|..:|             |||.|
Human   341 VDPP---FRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGF 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	105/288 (36%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	88/199 (44%)
RPS6KB2	NP_003943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		S_TKc	67..328	CDD:214567	108/296 (36%)
		STKc_p70S6K	70..392	CDD:270736	121/357 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..482
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12529391	471..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810