Protein Alignment S6KL and RPS6KB1

DIOPT Version :10

• Sequence 1: NP_524861.2
• Gene: S6KL / 45970
• FlyBaseID: FBgn0283473
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 107/294 - (36%)
• Similarity: 150/294 - (51%)
• Gaps: 54/294 - (18%)

  Fly   152 ETSKN--------DLYRIDHLVAKGAFGVVFKVS--SKSDISQCYALKVLKKSKLIEDNSVRQIK 206
            |||.|        :.:.:..::.||.:|.||:|.  :.::..:.:|:|||||:.:     ||..|
Human    76 ETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMI-----VRNAK 135

  Fly   207 DEAD-------IQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKITH---FSIDLVRLY 261
            |.|.       :::|  .|||||..|..:|....|:::.||:..||||.::..   |..|....|
Human   136 DTAHTKAERNILEEV--KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 198

  Fly   262 IGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSK-WLKLGANTRTMCGTFKYMAPE 325
            :.||::||..||..||||||.|||||:|..|.|:|||||||.| .:..|..|.|.|||.:|||||
Human   199 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 263

  Fly   326 ILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIAQINGCLQDSD 390
            ||....:..|||||:||.:...|||               ...|..|.:...:|.:|..|..:
Human   264 ILMRSGHNRAVDWWSLGALMYDMLT---------------GAPPFTGENRKKTIDKILKCKLN-- 311

  Fly   391 GDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQRI 424
                  ||   .:||.|.||:|:|||......|:
Human   312 ------LP---PYLTQEARDLLKKLLKRNAASRL 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	86/199 (43%)
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		TOS motif	28..32
		STKc_p70S6K	94..416	CDD:270736	103/276 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399
		Autoinhibitory domain	424..525