DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and PRKCQ

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_005252553.1	Gene:	PRKCQ / 5588	HGNCID:	9410	Length:	740	Species:	Homo sapiens

Alignment Length:	331	Identity:	103/331 - (31%)
Similarity:	152/331 - (45%)	Gaps:	43/331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 WHRPLTNSIFNSHFKETSKN------------DLYRIDHLVAKGAFGVVFKVSSKSDISQCYALK 189
            |..||.......|..|...|            :.:.:..::.||:||.||....|. .:|.:|:|
Human   380 WESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKK-TNQFFAIK 443

  Fly   190 VLKKSKLIEDNSVRQIKDEADIQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKIT--- 251
            .|||..::.|:.|.....|..:..:...|||:......:|.:.||..:.||:..|:|...|.
Human   444 ALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCH 508

  Fly   252 HFSIDLVRLYIGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSKWLKLG-ANTRTM 315
            .|.:.....|..||.|.|.|||:.||:|||.|.:||||.:..|||:.|||:.|...|| |.|.|.
Human   509 KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF 573

  Fly   316 CGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIA 380
            |||..|:|||||.|:.|.|:||||:.||:..:||..:||            ...:|......||.
Human   574 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSP------------FHGQDEEELFHSIR 626

  Fly   381 QINGCLQDSDGDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQRIRSVMALQRIAIYKDYNLSSKQ 445
            ..|           .|.|   :.|..|.:|:|.||...||.:|:.....:::..::::.|....:
Human   627 MDN-----------PFYP---RWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELE 677

  Fly   446 LLSLSP 451
            ...:.|
Human   678 RKEIDP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	95/275 (35%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	78/190 (41%)
PRKCQ	XP_005252553.1	C1_1	194..246	CDD:278556
		C1_1	266..318	CDD:278556
		STKc_nPKC_theta	408..738	CDD:270770	97/303 (32%)
		S_TKc	414..668	CDD:214567	95/280 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910