DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and PRKCH

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_006246.2	Gene:	PRKCH / 5583	HGNCID:	9403	Length:	683	Species:	Homo sapiens

Alignment Length:	361	Identity:	114/361 - (31%)
Similarity:	163/361 - (45%)	Gaps:	70/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 LTNSIFNSHFKETSKN--------------DLYRIDHLVAKGAFGVVF--KVSSKSDISQCYALK 189
            ::.|......||:||.              |.:....::.||:||.|.  :|....|:   ||:|
Human   323 VSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDL---YAVK 384

  Fly   190 VLKKSKLIEDNSVRQIKDEADIQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGEL---FSKIT 251
            ||||..:::|:.|.....|..|..:..:|||:.:....:|....|..:.|:|..|:|   ..|..
Human   385 VLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSR 449

  Fly   252 HFSIDLVRLYIGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSK-WLKLGANTRTM 315
            .|.....|.|..||..||.|||:.||||||.|.:|:||..:.|.||.|||:.| .:..|..|.|.
Human   450 RFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATF 514

  Fly   316 CGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIA 380
            |||..|:|||||....||.||||||:||:..:||...:|          ...|.||.|..|
Human   515 CGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAP----------FEAENEDDLFEA---- 565

  Fly   381 QINGCLQDSDGDSEDFLPEEVQHLT--HE-GRDVLRKLLTIEPRQRIRSVM-----ALQRIAIYK 437
                           .|.:||.:.|  || ...:|:..:|..|..|:.|:.     |:.|...:|
Human   566 ---------------ILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFK 615

  Fly   438 DYN---LSSKQLLSLSPREIIARDGIRIYED-RHFD 469
            :.:   |:.:|:      |...|..|:..|| .:||
Human   616 EIDWAQLNHRQI------EPPFRPRIKSREDVSNFD 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	97/285 (34%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	79/192 (41%)
PRKCH	NP_006246.2	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..225	CDD:278556
		C1_1	246..298	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..342		5/18 (28%)
		S_TKc	355..614	CDD:214567	98/290 (34%)
		STKc_nPKC_eta	359..681	CDD:270742	108/325 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910