DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6KL and PRKCE

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_005391.1	Gene:	PRKCE / 5581	HGNCID:	9401	Length:	737	Species:	Homo sapiens

Alignment Length:	446	Identity:	117/446 - (26%)
Similarity:	180/446 - (40%)	Gaps:	111/446 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AHTNQPTQSHPPGDEEQ----PVQSQQQQLSTWSLGSLSGGRLNWSFSGARNSFRHRNKATRKSL 124
            |.:.||.....|.:|::    |.....|::                        :......||:|
Human   327 AESPQPASGSSPSEEDRSKSAPTSPCDQEI------------------------KELENNIRKAL 367

  Fly   125 TSLHGSRRGKTQWHRPLTNSIFNSHFKETSKN-------------DLYRIDHLVAKGAFGVVFKV 176
            :.   ..||:.  ||..::.  :.......:|             |.:....::.||:||.|...
Human   368 SF---DNRGEE--HRAASSP--DGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLA 425

  Fly   177 SSKSDISQCYALKVLKKSKLIEDNSVRQIKDEADIQKVCGHHPFIVKQIDLWQNRHNLHILSEYV 241
            ..|.. .:.||:|||||..:::|:.|.....|..|..:...||::.:....:|.:..|..:.|||
Human   426 ELKGK-DEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYV 489

  Fly   242 PNGELFSKITH---FSIDLVRLYIGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLS 303
            ..|:|..:|..   |.....|.|..|:..||.|||..|:||||.|.:||||..:.|.||.|||:.
Human   490 NGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC 554

  Fly   304 K-WLKLGANTRTMCGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSPNIKRHLLRRRESV 367
            | .:..|..|.|.|||..|:|||||....||.:||||||||:..:|:..:.|
Human   555 KEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPP------------- 606

  Fly   368 EPEDGLSNAPSIAQINGCLQDSDGDSEDFLPEEVQH--------LTHEGRDVLRKLLTIEPRQRI 424
                                 .:.|:||.|.|.:.|        |:.|...:|:..:|..|.:|:
Human   607 ---------------------FEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRL 650

  Fly   425 RSVM------ALQRIAIYKDYN---LSSKQLL-SLSPREIIARDGIRIYEDRHFDQ 470
            ..|.      |:::...:|:.:   |..|::. ...||....||      ..:|||
Human   651 GCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRD------VNNFDQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	91/289 (31%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	76/190 (40%)
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385
		Interaction with actin. /evidence=ECO:0000250	223..228
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..356		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398		5/31 (16%)
		STKc_nPKC_epsilon	412..732	CDD:270743	101/330 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910