DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and prkcq

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_009298659.1	Gene:	prkcq / 555521	ZFINID:	ZDB-GENE-041210-195	Length:	719	Species:	Danio rerio

Alignment Length:	464	Identity:	132/464 - (28%)
Similarity:	194/464 - (41%)	Gaps:	85/464 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TSQWPQGAAELGASASD-----HHYHQ----------EELYQEQQQQQQQPQQEQPSSRRIQFQA 64
            |..|  |.|..|....:     ||..|          ::|..|.....:..||:..|||..:...
Zfish   256 TLLW--GLARQGLKCEECGMNVHHKCQKKVANLCGVNQKLMAEALAMIESTQQQARSSRDTETVG 318

  Fly    65 HTNQPTQSHPPGDEEQPVQSQQQQLSTWSLGSLSGGRLNWSFSGARNSFRHRNKATRK-----SL 124
            ... |..:..||...:|                 .|||      |.:.........||     |.
Zfish   319 REG-PVSADQPGVIREP-----------------SGRL------AISPLTPAPPLPRKEHQGISW 359

  Fly   125 TSLHGSRRGKTQWHRPLTNSIFNSHFKETSKNDLYRIDHLVAKGAFGVVFKVSSKSDISQCYALK 189
            .|....||...:...||..:....|.|.|.  |.:.:..::.||:||.||....|.. .|.:|:|
Zfish   360 DSPADGRRPSLEEPEPLYATPRKEHHKFTI--DSFILHKMLGKGSFGKVFLAELKGS-GQFFAVK 421

  Fly   190 VLKKSKLIEDNSVRQIKDEADIQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKI-THF 253
            .|||..::.|:.|.....|..:..:...|||:......:|.:.||..:.||:..|:|...| |..
Zfish   422 ALKKDVVLMDDDVECTMVERRVLSLAWDHPFLTHLYCTFQTKENLFFVMEYLNGGDLMFHIQTCH 486

  Fly   254 SIDLVR--LYIGEIALALDFLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSKWLKLG-ANTRTM 315
            ..||.|  .|..||...|.|||:.||:|||.|.:||||....|||:.|||:.|...:| |.|.|.
Zfish   487 RFDLPRSTFYAAEIICGLQFLHSKGIVYRDLKLDNILLDTDGHIKIADFGMCKENIIGEARTCTF 551

  Fly   316 CGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSP---NIKRHLLRRRESVEPEDGLSNAP 377
            |||..|:|||||.|:.||.:||||:.||:..:||..:||   :.:..|.   :|:..:|
Zfish   552 CGTPDYIAPEILLGQKYGTSVDWWSFGVLLYEMLIGQSPFHGHDEEELF---QSIRTDD------ 607

  Fly   378 SIAQINGCLQDSDGDSEDFLPEEVQHLTHEGRDVLRKLLTIEPRQRIRSVMALQRIAIYKDYNLS 442
                                |...:.||.:.||:|.||...||.:|:.....:::...:::.:.|
Zfish   608 --------------------PCYPRWLTRDARDILVKLFVREPERRLGVKGNIRQHPFFRETDWS 652

  Fly   443 SKQLLSLSP 451
            :.:...:.|
Zfish   653 ALEERQVEP 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	95/278 (34%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	79/190 (42%)
prkcq	XP_009298659.1	C1_1	166..218	CDD:278556
		C1_1	238..290	CDD:278556	8/35 (23%)
		STKc_nPKC_theta	386..716	CDD:270770	100/308 (32%)
		S_TKc	392..646	CDD:214567	95/283 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910