DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and Sgk2

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_038759.1	Gene:	Sgk2 / 27219	MGIID:	1351318	Length:	367	Species:	Mus musculus

Alignment Length:	320	Identity:	102/320 - (31%)
Similarity:	146/320 - (45%)	Gaps:	64/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LVAKGAFGVVFKVSSKSDISQCYALKVLKKSKLIEDNSVRQIKDEADIQKVCGHHPFIVKQIDLW 228
            ::.||.:|.|.....||| ...||:|||:|..::::.....|..|.::......|||:|.....:
Mouse    40 VIGKGNYGKVLLAKRKSD-GAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNVRHPFLVGLRYSF 103

  Fly   229 QNRHNLHILSEYVPNGELF---SKITHFSIDLVRLYIGEIALALDFLHNAGIIYRDAKPENILLT 290
            |....|:.:.:||..||||   .:...|.....|.|..|:|.|:.:||:..|||||.|||||||.
Mouse   104 QTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKPENILLD 168

  Fly   291 EQFHIKLTDFGLSK-WLKLGANTRTMCGTFKYMAPEILCGEPYGHAVDWWALGVIACQMLTQKSP 354
            .|.|:.||||||.| .::....|.|.|||.:|:|||:|..|||..|||||.||.:..:||....|
Mouse   169 CQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPP 233

  Fly   355 NIKRHLLRRRESV--EPEDGLSNAPSIAQINGCLQDSDGDSEDFLPEEVQHLTHEGR-----DVL 412
            .....:.:..|::  :|          .||.|                       ||     |:|
Mouse   234 FFNTDVAQMYENILHQP----------LQIPG-----------------------GRTVAACDLL 265

  Fly   413 RKLLTIEPRQRIRSVMALQRIAIYKDYNLSSKQLLSLSPREIIARDGIRIYEDRHFDQLT 472
            :.||..:.|||:.|          |:..|..|..:..||..         ::|.:..:||
Mouse   266 QGLLHKDQRQRLGS----------KEDFLDIKNHMFFSPIN---------WDDLYHKRLT 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	94/277 (34%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	78/190 (41%)
Sgk2	NP_038759.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PKc_like	39..359	CDD:389743	102/320 (32%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		1/9 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810