Protein Alignment S6KL and Prkci

DIOPT Version :10

• Sequence 1: NP_524861.2
• Gene: S6KL / 45970
• FlyBaseID: FBgn0283473
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_032883.2
• Gene: Prkci / 18759
• MGIID: 99260
• Length: 595
• Species: Mus musculus
• Alignment Length: 280
• Identity: 93/280 - (33%)
• Similarity: 144/280 - (51%)
• Gaps: 41/280 - (14%)

  Fly   157 DLYRIDHLVAKGAFGVVFKVSSKSDISQCYALKVLKKSKLIEDNSVRQIKDEADIQKVCGHHPFI 221
            ||.|:   :.:|::..|..|..|. ..:.||:||:||..:.:|..:..::.|..:.:...:|||:
Mouse   254 DLLRV---IGRGSYAKVLLVRLKK-TDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 314

  Fly   222 VKQIDLWQNRHNLHILSEYVPNGEL---FSKITHFSIDLVRLYIGEIALALDFLHNAGIIYRDAK 283
            |.....:|....|..:.|||..|:|   ..:......:..|.|..||:|||::||..||||||.|
Mouse   315 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 379

  Fly   284 PENILLTEQFHIKLTDFGLSK-WLKLGANTRTMCGTFKYMAPEILCGEPYGHAVDWWALGVIACQ 347
            .:|:||..:.||||||:|:.| .|:.|..|.|.|||..|:|||||.||.||.:||||||||:..:
Mouse   380 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFE 444

  Fly   348 MLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIAQINGCLQDSDGDSEDFLPEEV--------QHL 404
            |:..:||                         ..|.|...:.|.::||:|.:.:        :.|
Mouse   445 MMAGRSP-------------------------FDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 484

  Fly   405 THEGRDVLRKLLTIEPRQRI 424
            :.:...||:..|..:|::|:
Mouse   485 SVKAASVLKSFLNKDPKERL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	76/190 (40%)
Prkci	NP_032883.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Regulatory domain. /evidence=ECO:0000250	2..252
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A. /evidence=ECO:0000250	72..91
		Pseudosubstrate	125..134
		C1_aPKC	139..193	CDD:410344
		STKc_aPKC_iota	232..595	CDD:270769	93/280 (33%)