DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6KL and prkcea

DIOPT Version :9

Sequence 1:	NP_524861.2	Gene:	S6KL / 45970	FlyBaseID:	FBgn0283473	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_005156350.1	Gene:	prkcea / 100005075	ZFINID:	ZDB-GENE-030131-8191	Length:	744	Species:	Danio rerio

Alignment Length:	427	Identity:	118/427 - (27%)
Similarity:	176/427 - (41%)	Gaps:	85/427 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AAELGASASDHHYHQEELYQEQQQQQ-----QQPQQ---EQPSSRRIQFQAHTNQPTQSHPPGDE 78
            |.::....||.....:::....|:::     |.|||   |.|||.  :.....:.||.   |.|:
Zfish   300 ARKIAKVLSDLGVTPDKISNSTQRRKKLTPGQDPQQSTTEAPSSE--ESDRCKSAPTS---PCDQ 359

  Fly    79 EQPVQSQQQQLSTWSLGSLSGGRLNWSFSGARNSFRHRNKATRKSLTSLHGSRRGKTQWHRPLTN 143
            .:             |..|...|...|| |..:.....:..:....|.:.|...|
Zfish   360 AE-------------LAELESIRKALSF-GQEHKSSSSSSCSGVQSTEIEGRENG---------- 400

  Fly   144 SIFNSHFKETSKNDLYRIDHLVAKGAFGVVFKVSSKSDISQCYALKVLKKSKLIEDNSVRQIKDE 208
            .:.....|..|..| :....::.||:||.|.....|. ..:.||:|||||..:::|:.|.....|
Zfish   401 DLKTVQTKRMSLTD-FSFIKVLGKGSFGKVMLAELKG-TDEVYAVKVLKKDVILQDDDVDCTLTE 463

  Fly   209 ADIQKVCGHHPFIVKQIDLWQNRHNLHILSEYVPNGELFSKITH---FSIDLVRLYIGEIALALD 270
            ..|..:...||::.:....:|.:..|..:.|||..|:|..:|..   |.....|.|..|:..||.
Zfish   464 KRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALM 528

  Fly   271 FLHNAGIIYRDAKPENILLTEQFHIKLTDFGLSK-WLKLGANTRTMCGTFKYMAPEILCGEPYGH 334
            |||..|:||||.|.:||||..:.|.||.|||:.| .:..|..|.|.|||..|:|||||....||.
Zfish   529 FLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 593

  Fly   335 AVDWWALGVIACQMLTQKSPNIKRHLLRRRESVEPEDGLSNAPSIAQINGCLQDSDGDSEDFLPE 399
            :||||||||:..:|:..:.|                                  .:.|:||.|.|
Zfish   594 SVDWWALGVLMYEMMAGQPP----------------------------------FEADNEDDLFE 624

  Fly   400 EVQH--------LTHEGRDVLRKLLTIEPRQRIRSVM 428
            .:.|        |:.|...:|:..:|..|.:|:..|:
Zfish   625 SILHDDVLYPVWLSKEAVSILKAFMTKNPSKRLGCVV 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6KL	NP_524861.2	S_TKc	159..431	CDD:214567	90/282 (32%)
S6KL	NP_524861.2	STKc_AGC	167..>354	CDD:270693	76/190 (40%)
prkcea	XP_005156350.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_1	173..223	CDD:278556
		C1_1	247..299	CDD:278556
		S_TKc	415..675	CDD:214567	90/282 (32%)
		STKc_nPKC_epsilon	419..739	CDD:270743	90/278 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910