DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gwl and Mastl

DIOPT Version :9

Sequence 1:	NP_524860.2	Gene:	gwl / 45969	FlyBaseID:	FBgn0260399	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_080255.3	Gene:	Mastl / 67121	MGIID:	1914371	Length:	865	Species:	Mus musculus

Alignment Length:	899	Identity:	316/899 - (35%)
Similarity:	460/899 - (51%)	Gaps:	168/899 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQ 116
            |:|::|.|:|||||||||||:||.|..   :|:|:||::|::||||||..||..||:|||||:|.
Mouse    29 PSIEEFTIVKPISRGAFGKVYLGQKGG---KLYAVKVVKKADMINKNMTHQVQAERDALALSKSP 90

  Fly   117 FCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRD 181
            |.|.|:|||||.|.:||:|||::|||:||||.::|||||..|..|::|:.:||.|||:|||:|||
Mouse    91 FVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEEMAIKYISEVALALDYLHRHGIIHRD 155

  Fly   182 IKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLN------ARTPGQLLSLTSHLSF 240
            :||||||:|:.||:|||||||||:.:.||:.:.|::. :|:::      :|||||:|||.|.|.|
Mouse   156 LKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILT-TPSMSKPKQDYSRTPGQVLSLISSLGF 219

  Fly   241 ------GSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTS 299
                  ..:...|.|.:..|......|.:.                        ..|::..|.||
Mouse   220 FTPVGEKDQDSANMFSAPKSAAQLSRGFIC------------------------PMSVDQKEPTS 260

  Fly   300 -DSKISGVSPFFSAEEANESITHTCTTNVNPQ------DSSSSCSFHTCNSADLSKC-SPP---- 352
             .||:  :...|....:|..|...|.|:...|      .||:|...||..|:..|:| |.|
Mouse   261 YSSKL--LKSCFETLSSNPEIPVKCLTSNLLQCRKRLGTSSTSSQSHTFVSSVESECHSNPKWER 323

  Fly   353 ----LESKDGAAAGNAIPS---------KRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKI 404
                .||...|.:.||:..         |.:.|..|..:|...........||..|     ||:
Mouse   324 DCQSTESSGCAMSWNAVEMLYAKSTSAIKTKTELELALSPIHDSSAIPAAGSNQVT-----LPR- 382

  Fly   405 DNAIEASFEFSMVRRRSVDERNRISKGPEDSGVSSRKGDDYSSCHLNLNSESTAS------SIEK 463
                :...|.|...|...:|...|.||......||::         ::||.:|:.      :.::
Mouse   383 ----KCFREISWEARDPDNENMTIDKGQSGFCQSSQR---------SVNSSATSEEHLGKRNYKR 434

  Fly   464 N---VDN-----LSQSKEDFSCSDY--SRSYNVTNGNEMSGINMNSPFRNLSK-HFKRPDFL--- 514
            |   ||:     :.|||:  :|::|  ::.......|:.:|:........||. ..::.|:.
Mouse   435 NFHLVDSSPCQEIMQSKK--NCTEYEANKERQGCRANQSTGLTTEVQNLKLSGCESQQLDYANKE 497

  Fly   515 --------RGMKRKINLVNRSDN-MSSMDTD-------GCSSSNG-STNTGLTQEIEILNIGSST 562
                    |....|:::...:.| ||.:|.|       .|.|||. .::.....:...::..||.
Mouse   498 NIVTYLTDRQTPEKLHIPTIAKNLMSELDEDCELSSKKDCLSSNSVCSDEDRALKTTCVDSDSSF 562

  Fly   563 PKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKAT 627
            |......||     |::::|..|: .|......|.|..::..........||:.|..     ...
Mouse   563 PGVSMMESS-----LEIQALEPDK-SIRDYSFEEPNTEDLFVLPKCQENSLPQDDCH-----ACI 616

  Fly   628 RFALPLSIENKKREHATADKMSGIQY-----HLKLSDDPTMSPIN-----------HGAGNLP-- 674
            :.:..:|....|...|...|::.:.:     |:..|.:...|.|:           ..:|:.|
Mouse   617 QDSSQVSAHPSKAPKALTSKINVVAFRSFNSHINASTNSEPSKISITSLDAMDISCDYSGSYPMA 681

  Fly   675 -------------KTPKNVNINTPFRTPKSVRRGAR-VSNERILGTPDYLAPELLLKQGHGPAVD 725
                         :||..|.:.|.:||||||||||. |.:.|||||||||||||||...||||||
Mouse   682 VSPTEKGRHYTSHQTPNQVKLGTSYRTPKSVRRGAAPVDDGRILGTPDYLAPELLLGTAHGPAVD 746

  Fly   726 WWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNERPA 790
            |||||||.:||:||||||||||||:||.|||.::|.||||:|.||..:..|:::|||:|.::|..
Mouse   747 WWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAMDMLLTIDDSKRAG 811

  Fly   791 AKEVQQMRHFACIDWENIGNTEPPFVPTPDNPTDTGYFDARNNLQHLQLSNFAL 844
            .:|::|...|:.:||||:.:...||||.||:.|||.||:||||.|||.:|.|:|
Mouse   812 MRELKQHPLFSEVDWENLQHQTMPFVPQPDDETDTSYFEARNNAQHLTISGFSL 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	114/214 (53%)
		S_TKc	57..>205	CDD:214567	94/147 (64%)
		PKc_like	<655..835	CDD:304357	103/206 (50%)
Mastl	NP_080255.3	STKc_MASTL	29..>222	CDD:270761	112/196 (57%)
		S_TKc	34..>194	CDD:214567	98/163 (60%)
		PKc_like	<658..856	CDD:304357	102/197 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842503
Domainoid	1	1.000	201	1.000	Domainoid score	I3011
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1687
Isobase	1	0.950	-	0	Normalized mean entropy	S4209
OMA	1	1.010	-	-		QHG47788
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007311
OrthoInspector	1	1.000	-	-		oto94565
orthoMCL	1	0.900	-	-		OOG6_107501
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5271
SonicParanoid	1	1.000	-	-		X1837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830