Protein Alignment gwl and Pkc53E

DIOPT Version :10

• Sequence 1: NP_524860.2
• Gene: gwl / 45969
• FlyBaseID: FBgn0260399
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Alignment Length: 821
• Identity: 130/821 - (15%)
• Similarity: 190/821 - (23%)
• Gaps: 509/821 - (61%)

  Fly    27 DSEQLLDKIN---------ILTTKPENHSQNAK-LPTIKDFVIIKPISRGAFGKVFLGYKNNDSK 81
            |.||.|.|:.         ::.:....|:.:.| :....||..||.:.:|:||||.|. :...|:
  Fly   310 DDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLA-ERKGSE 373

  Fly    82 RLFAIKVMRKSEMINKNMVSQVITERNALAL-SRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKS 145
            .|:|||:::|..:|..:.|...:.|:..||| .:..|.|.|....|::..::.||||:.||||..
  Fly   374 ELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMF 438

  Fly   146 LLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRD 210
            .:..||.|.||.|.||.||:...|.:||..||::||:|.||:||.:.||||:.|||:
  Fly   439 QIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGM-------- 495

  Fly   211 LEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAIN 275
                                                                             
  Fly   496 ----------------------------------------------------------------- 495

  Fly   276 KHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHT 340
                                                           |..|:
  Fly   496 -----------------------------------------------CKENI------------- 500

  Fly   341 CNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKID 405
                                                                             
  Fly   501 ----------------------------------------------------------------- 500

  Fly   406 NAIEASFEFSMVRRRSVDERNRISKGPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQ 470
                                                                             
  Fly   501 ----------------------------------------------------------------- 500

  Fly   471 SKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDT 535
                                                                             
  Fly   501 ----------------------------------------------------------------- 500

  Fly   536 DGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVA 600
                                  :|..|.|
  Fly   501 ----------------------VGDKTTK------------------------------------ 507

  Fly   601 NVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSP 665
                                                                             
  Fly   508 ----------------------------------------------------------------- 507

  Fly   666 INHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALG 730
                                                ...|||||:|||::|.|.:|.:|||||.|
  Fly   508 ------------------------------------TFCGTPDYIAPEIILYQPYGKSVDWWAYG 536

  Fly   731 VCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNER-----PA 790
            |..||.:.|.|||:.|..:::|..|.:.|:.:|   ::||.|:.||.:..||..||:|     ..
  Fly   537 VLLYEMLVGQPPFDGEDEEELFAAITDHNVSYP---KSLSKEAKEACKGFLTKQPNKRLGCGSSG 598

  Fly   791 AKEVQQMRHFACIDWENIGNTE--PPFVPTPDNPTDTGYFD 829
            .::|:....|..||||.|.|.|  |||.|...:..|...||
  Fly   599 EEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFD 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	Protein Kinases, catalytic domain	52..>255	CDD:473864	63/203 (31%)
		Protein Kinases, catalytic domain	<655..835	CDD:473864	55/182 (30%)
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	121/778 (16%)