Protein Alignment gwl and MAST4

DIOPT Version :10

• Sequence 1: NP_524860.2
• Gene: gwl / 45969
• FlyBaseID: FBgn0260399
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_024301812.1
• Gene: MAST4 / 375449
• HGNCID: 19037
• Length: 2695
• Species: Homo sapiens
• Alignment Length: 799
• Identity: 140/799 - (17%)
• Similarity: 214/799 - (26%)
• Gaps: 481/799 - (60%)

  Fly    46 SQNAKL-----PTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVIT 105
            |.||.|     |...||..||.||.||:|.|:. .::.:|::.||:|.:.|..:|.:|.:.|...
Human   626 SSNASLKLRRKPRESDFETIKLISNGAYGAVYF-VRHKESRQRFAMKKINKQNLILRNQIQQAFV 689

  Fly   106 ERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQ 170
            ||:.|..:.:.|.||::.|.::..::.:||||:.|||..:|:...|......||.|.||.|:||:
Human   690 ERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALE 754

  Fly   171 YLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLT 235
            |||.:||||||:||||:|::|.||:|||||||||:.                        |:|:|
Human   755 YLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVG------------------------LMSMT 795

  Fly   236 SHLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSD 300
            ::|..|
Human   796 TNLYEG----------------------------------------------------------- 801

  Fly   301 SKISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAI 365
                                                                             
Human   802 ----------------------------------------------------------------- 801

  Fly   366 PSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISK 430
                                              |:.|                   |.|
Human   802 ----------------------------------HIEK-------------------DAR----- 808

  Fly   431 GPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGI 495
                                                                             
Human   809 ----------------------------------------------------------------- 808

  Fly   496 NMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIGS 560
                            :||
Human   809 ----------------EFL---------------------------------------------- 811

  Fly   561 STPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLK 625
                                                                             
Human   812 ----------------------------------------------------------------- 811

  Fly   626 ATRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPK 690
                                                                             
Human   812 ----------------------------------------------------------------- 811

  Fly   691 SVRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNI 755
                     ::::.|||:|:|||::|:||:|..|||||:|:..|||:.|..||..:||:::|..:
Human   812 ---------DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQV 867

  Fly   756 LNKNIEWPEGDEALSVESMEAVELLLTMDPNER---PAAKEVQQMRHFACIDWENIGNTEPPFVP 817
            ::..|.|||.|||...::.:.:.|||..:|.||   ..|.||:|.|.|..:||.::...:..|:|
Human   868 ISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIP 932

  Fly   818 TPDNPTDTGYFDARNNLQH 836
            ..::..||.|||.|:...|
Human   933 QLESEDDTSYFDTRSEKYH 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	Protein Kinases, catalytic domain	52..>255	CDD:473864	74/202 (37%)
		Protein Kinases, catalytic domain	<655..835	CDD:473864	55/182 (30%)
MAST4	XP_024301812.1	DUF1908	330..603	CDD:462637
		STKc_MAST	641..920	CDD:270760	124/751 (17%)
		PDZ_MAST4	1210..1304	CDD:467289
		PHA03247	<1883..2261	CDD:223021
		PHA03247	<2207..2506	CDD:223021