DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gwl and MAST1

DIOPT Version :9

Sequence 1:	NP_524860.2	Gene:	gwl / 45969	FlyBaseID:	FBgn0260399	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_851603.1	Gene:	MAST1 / 353118	RGDID:	631372	Length:	1570	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	140/794 - (17%)
Similarity:	212/794 - (26%)	Gaps:	476/794 - (59%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SQNAKLPTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNAL 110
            |:..|.|...||..||.||.||:|.|:| .::.|:::.||:|.:.|..:|.:|.:.|...||:.|
  Rat   365 SKAKKPPGESDFDTIKLISNGAYGAVYL-VRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDIL 428

  Fly   111 ALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQH 175
            ..:.:.|.|.:|.|.::..::.:||||:.|||..:||...|......||.|.||.|:||:|||.:
  Rat   429 TFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNY 493

  Fly   176 GIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSF 240
            ||||||:||||:|::|.||:|||||||||:.                        |:|||::|..
  Rat   494 GIVHRDLKPDNLLITSMGHIKLTDFGLSKMG------------------------LMSLTTNLYE 534

  Fly   241 GSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISG 305
            |
  Rat   535 G---------------------------------------------------------------- 535

  Fly   306 VSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRR 370

  Rat   536 ----------------------------------------------------------------- 535

  Fly   371 VEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPEDS 435
                                         |:.|                   |.|
  Rat   536 -----------------------------HIEK-------------------DAR---------- 542

  Fly   436 GVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSP 500

  Rat   543 ----------------------------------------------------------------- 542

  Fly   501 FRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIGSSTPKK 565
                       :||
  Rat   543 -----------EFL--------------------------------------------------- 545

  Fly   566 RKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFA 630

  Rat   546 ----------------------------------------------------------------- 545

  Fly   631 LPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRG 695

  Rat   546 ----------------------------------------------------------------- 545

  Fly   696 ARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNI 760
                ::::.|||:|:|||::|:||:|..|||||:|:..|||:.|..||..:||:::|..:::.:|
  Rat   546 ----DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDI 606

  Fly   761 EWPEGDEALSVESMEAVELLLTMDPNER---PAAKEVQQMRHFACIDWENIGNTEPPFVPTPDNP 822
            .||||||||..::...:..||..:|..|   ..|.||:|...|..:||..:...:..|:|..::.
  Rat   607 LWPEGDEALPTDAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESE 671

  Fly   823 TDTGYFDARNNLQH 836
            .||.|||.|::..|
  Rat   672 DDTSYFDTRSDRYH 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	77/202 (38%)
		S_TKc	57..>205	CDD:214567	68/147 (46%)
		PKc_like	<655..835	CDD:304357	54/182 (30%)
MAST1	NP_851603.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..80
		DUF1908	61..337	CDD:286070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..377		4/11 (36%)
		STKc_MAST	375..654	CDD:270760	126/751 (17%)
		S_TKc	376..649	CDD:214567	124/745 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..911
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..967
		PDZ_signaling	970..1052	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1061..1186
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1294
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900