DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gwl and ppk31

DIOPT Version :9

Sequence 1:	NP_524860.2	Gene:	gwl / 45969	FlyBaseID:	FBgn0260399	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_595486.1	Gene:	ppk31 / 2541095	PomBaseID:	SPBC725.06c	Length:	1032	Species:	Schizosaccharomyces pombe

Alignment Length:	858	Identity:	159/858 - (18%)
Similarity:	256/858 - (29%)	Gaps:	439/858 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IDY-KTPKKTHSLIDSEQLLDK-----------INILTTKPENHSQNAK-----LP-TIKDFVII 60
            ||| |..|.:...:|...|.::           ::.||...:..|.|.:     .| ::.:|:::
pombe   467 IDYFKAVKGSIEDLDVRPLKNRQKFVNKFYASIVHFLTESMQFPSHNDRRFGDNTPHSLDEFILL 531

  Fly    61 KPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSR-SQFCVSLFYS 124
            |.|:|||:|:|:|. |...|.:.||:|::.||.:.:...:..::.|:..:.:.| ....|.|:|:
pombe   532 KEINRGAYGRVYLA-KKRSSGKYFALKMIPKSSLDSLKKIKGLLLEKRNMHIQRYGPNTVKLYYA 595

  Fly   125 LQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLL 189
            ..|..|:.|||:|..|||.::|:...|...|.....|.||::.|::.|||.||:|.||||.|||:
pombe   596 FDSGDYLCLVMDYFNGGDCETLIQKLGPLPEQWVCQYAAELLNAIELLHQDGIIHHDIKPANMLV 660

  Fly   190 SSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSS 254
            ..:||::|||||||:                   |.....::..||..:||
pombe   661 DETGHIRLTDFGLSE-------------------NVEEKKEVYKLTKRMSF-------------- 692

  Fly   255 GQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESI 319

pombe   693 ----------------------------------------------------------------- 692

  Fly   320 THTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCK 384
                                              |.|.|                         .
pombe   693 ----------------------------------EQKHG-------------------------N 698

  Fly   385 LAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPEDSGVSSRKGDDYSSCH 449
            |.||..           ||       .|||  ||.                 |.:.:|
pombe   699 LYEQLQ-----------PK-------KFEF--VRY-----------------VRNYRG------- 719

  Fly   450 LNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFL 514
                          |:|.|.:::.....|||:                |...::|.      ||
pombe   720 --------------NIDELEKAESPQQNSDYA----------------NDSVQHLL------DF- 747

  Fly   515 RGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKV 579
                 .||      ||
pombe   748 -----DIN------NM------------------------------------------------- 752

  Fly   580 RSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLSIENKKREHAT 644
                 ||..|:.|:.                                         :.:|:|:.|
pombe   753 -----DETAIHMLMN-----------------------------------------QLEKKENRT 771

  Fly   645 ADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNERILGTPDY 709
            ..|                                                     :.|.|||:|
pombe   772 FIK-----------------------------------------------------KDISGTPNY 783

  Fly   710 LAPELLL----KQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEG-DEAL 769
            :|||:|:    :.|     |.||:|...:|.:||..||...|.:.::..|...:|.|.:. .|:.
pombe   784 MAPEILMGVDTQMG-----DIWAMGCVIFEMLTGTRPFEANTVKAIWARIERNDIGWTKRVKESC 843

  Fly   770 SVESMEAVELLLTMDPNERPAA---KEVQQMRHFACIDWENIGNTEPPFVPTPDNPTDTGYFDA- 830
            |.|:::.:..|:..|.|:|..:   :|:::...|..|.|:|:.:...||||..:|..|..||:.
pombe   844 SKEAVDLITKLMDPDCNKRLGSNGYQEIKKHPFFRTIKWDNLNSGPGPFVPQTENVEDLTYFEKN 908

  Fly   831 --------RNNLQ 835
                    :||.|
pombe   909 ISGSDNINKNNCQ 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	65/204 (32%)
		S_TKc	57..>205	CDD:214567	59/148 (40%)
		PKc_like	<655..835	CDD:304357	45/196 (23%)
ppk31	NP_595486.1	PAS	24..>83	CDD:238075
		S_TKc	528..877	CDD:214567	132/751 (18%)
		STKc_Rim15_like	531..883	CDD:270762	133/754 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100