Protein Alignment gwl and MAST3

DIOPT Version :9

• Sequence 1: NP_524860.2
• Gene: gwl / 45969
• FlyBaseID: FBgn0260399
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_006722762.2
• Gene: MAST3 / 23031
• HGNCID: 19036
• Length: 1419
• Species: Homo sapiens
• Alignment Length: 803
• Identity: 144/803 - (17%)
• Similarity: 213/803 - (26%)
• Gaps: 480/803 - (59%)

  Fly    42 PENHS---QNAKLPTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQV 103
            ||:.:   |:.:.|...||..||.||.||:|.|:| .::.|:::.||||.:.|..:|.:|.:.||
Human   450 PESRALVGQSRRKPCESDFETIKLISNGAYGAVYL-VRHRDTRQRFAIKKINKQNLILRNQIQQV 513

  Fly   104 ITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMA 168
            ..||:.|..:.:.|.||:|.|.::..::.:||||:.|||..:||...|......||.|.||.|:|
Human   514 FVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLA 578

  Fly   169 LQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLS 233
            |:|||.:||||||:||||:|::|.||:||||||||||
Human   579 LEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKI---------------------------- 615

  Fly   234 LTSHLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKT 298
                                     |:.|:||
Human   616 -------------------------GLMSMAT--------------------------------- 622

  Fly   299 SDSKISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGN 363
                                                                             
Human   623 ----------------------------------------------------------------- 622

  Fly   364 AIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRI 428
                                                                             
Human   623 ----------------------------------------------------------------- 622

  Fly   429 SKGPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMS 493
                                                                    |:..|:
Human   623 --------------------------------------------------------NLYEGH--- 628

  Fly   494 GINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNI 558
                                                                             
Human   629 ----------------------------------------------------------------- 628

  Fly   559 GSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGK 623
                                                                             
Human   629 ----------------------------------------------------------------- 628

  Fly   624 LKATRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRT 688
                       ||...||..
Human   629 -----------IEKDAREFI--------------------------------------------- 637

  Fly   689 PKSVRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFD 753
                       ::::.|||:|:|||::.:||:|..|||||:||..|||:.|..||..:||:::|.
Human   638 -----------DKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFG 691

  Fly   754 NILNKNIEWPEGDEALSVESMEAVELLLTMDPNER---PAAKEVQQMRHFACIDWENIGNTEPPF 815
            .:::..|.||||||||..::.:.:..||...|.:|   ....||:|...|..:||..:...:..|
Human   692 QVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 756

  Fly   816 VPTPDNPTDTGYFDARN-NLQHL 837
            ||..:...||.|||.|: ..:||
Human   757 VPQLEAEDDTSYFDTRSERYRHL 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	75/202 (37%)
		S_TKc	57..>205	CDD:214567	71/147 (48%)
		PKc_like	<655..835	CDD:304357	54/183 (30%)
MAST3	XP_006722762.2	DUF1908	152..432	CDD:286070
		STKc_MAST	467..746	CDD:270760	127/751 (17%)
		S_TKc	468..741	CDD:214567	125/745 (17%)
		PDZ	1052..1133	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900