DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gwl and MAST1

DIOPT Version :9

Sequence 1:	NP_524860.2	Gene:	gwl / 45969	FlyBaseID:	FBgn0260399	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_055790.1	Gene:	MAST1 / 22983	HGNCID:	19034	Length:	1570	Species:	Homo sapiens

Alignment Length:	798	Identity:	143/798 - (17%)
Similarity:	213/798 - (26%)	Gaps:	477/798 - (59%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ENHSQNAKLPT-IKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITE 106
            |..|..||.|. ..||..||.||.||:|.|:| .::.|:::.||:|.:.|..:|.:|.:.|...|
Human   359 EGRSSKAKKPPGENDFDTIKLISNGAYGAVYL-VRHRDTRQRFAMKKINKQNLILRNQIQQAFVE 422

  Fly   107 RNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQY 171
            |:.|..:.:.|.|.:|.|.::..::.:||||:.|||..:||...|......||.|.||.|:||:|
Human   423 RDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEY 487

  Fly   172 LHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTS 236
            ||.:||||||:||||:|::|.||:|||||||||:.                        |:|||:
Human   488 LHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMG------------------------LMSLTT 528

  Fly   237 HLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDS 301
            :|..|
Human   529 NLYEG------------------------------------------------------------ 533

  Fly   302 KISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAIP 366

Human   534 ----------------------------------------------------------------- 533

  Fly   367 SKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKG 431
                                             |:.|                   |.|
Human   534 ---------------------------------HIEK-------------------DAR------ 540

  Fly   432 PEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGIN 496

Human   541 ----------------------------------------------------------------- 540

  Fly   497 MNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIGSS 561
                           :||
Human   541 ---------------EFL----------------------------------------------- 543

  Fly   562 TPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKA 626

Human   544 ----------------------------------------------------------------- 543

  Fly   627 TRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKS 691

Human   544 ----------------------------------------------------------------- 543

  Fly   692 VRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNIL 756
                    ::::.|||:|:|||::|:||:|..|||||:|:..|||:.|..||..:||:::|..::
Human   544 --------DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI 600

  Fly   757 NKNIEWPEGDEALSVESMEAVELLLTMDPNER---PAAKEVQQMRHFACIDWENIGNTEPPFVPT 818
            :.:|.||||||||..|:...:..||..:|..|   ..|.||:|...|..:||..:...:..|:|.
Human   601 SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPH 665

  Fly   819 PDNPTDTGYFDARNNLQH 836
            .::..||.|||.|::..|
Human   666 LESEDDTSYFDTRSDRYH 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	77/203 (38%)
		S_TKc	57..>205	CDD:214567	68/147 (46%)
		PKc_like	<655..835	CDD:304357	55/182 (30%)
MAST1	NP_055790.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..80
		DUF1908	61..337	CDD:286070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..374		5/14 (36%)
		STKc_MAST	373..652	CDD:270760	127/751 (17%)
		S_TKc	374..647	CDD:214567	125/745 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..909
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..965
		PDZ_signaling	968..1050	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1200..1293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1305..1570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900