Protein Alignment Pep and CIZ1

DIOPT Version :9

• Sequence 1: NP_524858.1
• Gene: Pep / 45961
• FlyBaseID: FBgn0004401
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001244904.1
• Gene: CIZ1 / 25792
• HGNCID: 16744
• Length: 954
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 104/477 - (21%)
• Similarity: 162/477 - (33%)
• Gaps: 134/477 - (28%)

  Fly   102 PPSLLDLPRGGGGMGNR-NQRGGPMVSRGGGAGNRLNNRRGQG---GGFQNRGATGSGPKPPPKQ 162
            ||   |....||||... .:..|..||.     ..:.|....|   |..:||..     :.|...
Human   521 PP---DAVEAGGGMEKTLPEPVGTQVSM-----EEIQNESACGLDVGECENRAR-----EMPGVW 572

  Fly   163 GGGGIRK----QNAFDRAKKLLAKNANQNKKKEPTPGEKKIESPTKESPYASVPND---MFYCHL 220
            |.||..|    |::..||...:..          ||..:..:|.:......|.|:.   .|:|::
Human   573 GAGGSLKVTILQSSDSRAFSTVPL----------TPVPRPSDSVSSTPAATSTPSKQALQFFCYI 627

  Fly   221 CKKHMWDANSFENHIKGRTHLMMREGIEESYRLKANMIRQEAKIAEQLKSIEFDRLKRMGKSKQR 285
            ||........|::|:....| ..|.| |..:..:|.::        .|..:..|.|:...:....
Human   628 CKASCSSQQEFQDHMSEPQH-QQRLG-EIQHMSQACLL--------SLLPVPRDVLETEDEEPPP 682

  Fly   286 QLDYCTMCDLNFHGHISTHRKSEGH--------------------------LQLKKFLHPKCIEC 324
            : .:|..|.|.:.|.:..||:::.|                          :..|:.|.|.|..|
Human   683 R-RWCNTCQLYYMGDLIQHRRTQDHKPPTPRRDVFAHVPVQGWSTARLVTDMIAKQSLRPFCTVC 746

  Fly   325 NKEFATRIDYDTHLLSAEHLKKAAENNTKVGERKRQTLPISTEEEETRDLRLPQKRKKKPVKKE- 388
            |:.|.|...:..|:.|..|..||.|                                .|.::||
Human   747 NRYFKTPRKFVEHVKSQGHKDKAKE--------------------------------LKSLEKEI 779

  Fly   389 -GEAADGEAKKEGAGDGEGAEGDEAEGEEAKEGEEAADETKEGDELNESQEEEEVALPVDPEDCI 452
             |:..|.....:..|   ..||||.|.|:        ||.:|     |.:.|||:...|...|..
Human   780 AGQDEDHFITVDAVG---CFEGDEEEEED--------DEDEE-----EIEVEEELCKQVRSRDIS 828

  Fly   453 LDFNDGDEIPSEVDTRLPKYNWQRAVGPGLISKLECYECSVCSKFFDTEVTAEI-HSRTATHHRN 516
            .:...|.|          .|:...|.|...:..:..|.|.:|.||:.:...|:: |.::..|..|
Human   829 REEWKGSE----------TYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFEN 883

  Fly   517 FLKFINEK--SSDTKIAQKRAA 536
            ..|:...|  |..|:...:|.|
Human   884 LQKYKAAKNPSPTTRPVSRRCA 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pep	NP_524858.1	zf-C2H2_jaz	216..240	CDD:288983	6/23 (26%)
		C2H2 Zn finger	290..310	CDD:275371	6/19 (32%)
		C2H2 Zn finger	321..343	CDD:275371	7/21 (33%)
CIZ1	NP_001244904.1	ZnF_U1	622..651	CDD:197732	7/29 (24%)
		zf-C2H2_jaz	742..766	CDD:288983	7/23 (30%)
		ZnF_U1	854..887	CDD:197732	9/32 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C5JG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005683
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15491
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4717
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960