DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aly and LIN9

DIOPT Version :9

Sequence 1:	NP_001261348.1	Gene:	aly / 45960	FlyBaseID:	FBgn0004372	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_024302333.1	Gene:	LIN9 / 286826	HGNCID:	30830	Length:	581	Species:	Homo sapiens

Alignment Length:	476	Identity:	117/476 - (24%)
Similarity:	203/476 - (42%)	Gaps:	65/476 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CEENEFLANI--GLLSTTTMSRH-QLKKPRKMVAAW--QNDELFIKRP-NFAPRIRI-SEKPEIQ 75
            |...:.|.::  |.||.|...:: .|:|    ...|  :|....::.| ..:.|.|: |::.:.|
Human    84 CSSAKALVSLKEGSLSNTWNEKYSSLQK----TPVWKGRNTSSAVEMPFRNSKRSRLFSDEDDRQ 144

  Fly    76 GRIKPGVASKRTENFTKKPSNISVDVS-EDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRW 139
            ...:   :.||.:.....|...:..:| .|:||.:|            :|.||.|.||...:|:|
Human   145 INTR---SPKRNQRVAMVPQKFTATMSTPDKKASQK------------IGFRLRNLLKLPKAHKW 194

  Fly   140 IWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELERE 204
            ...|:..|.:|||......|....:.|..|.|.:..:.|..|..:||.|||.||.|:||.|.||.
Human   195 CIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERS 259

  Fly   205 ELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGNSFEGIVNGTVMGYDP 269
            .|:.:|:.:|.|||.|.   .:|.....:|..:||||.....|::.|.| ..:|:..|.:...|.
Human   260 ALKQKRQKIRLLQQRKV---ADVSQFKDLPDEIPLPLVIGTKVTARLRG-VHDGLFTGQIDAVDT 320

  Fly   270 QDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTK 334
            .:.||.|.|:|. .....::||.::.|:|....:|::...:..:.|.......:.      .||.
Human   321 LNATYRVTFDRT-GLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRL------HYTP 378

  Fly   335 ELLESVL-RVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMIT 398
            .|...:: |:.|:..:|.:.:..|..||.:.|..|...          .|.....||||:..::.
Human   379 PLQSPIITRLSKILMIKKEHIKKLREMNTEAEKLKSYS----------MPISIEFQRRYATIVLE 433

  Fly   399 LHRVNADILEPLRILHDYLVE------YQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEK 457
            |.::|.|:.:.|..:..|..|      .|..|:..:.:|         :|..:|::.::.|....
Human   434 LEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRR---------RCEEEAQEIVRHANSST 489

  Fly   458 FLK-IESDRTQEFVRNLHTIL 477
            ... :|::...:.:..|..||
Human   490 GQPCVENENLTDLISRLTAIL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aly	NP_001261348.1	DIRP	147..252	CDD:284095	37/104 (36%)
LIN9	XP_024302333.1	DIRP	200..304	CDD:310884	37/106 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I4944
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48430
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005813
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21689
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.860