DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aly and lin9

DIOPT Version :9

Sequence 1:	NP_001261348.1	Gene:	aly / 45960	FlyBaseID:	FBgn0004372	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_002941177.2	Gene:	lin9 / 100491065	XenbaseID:	XB-GENE-963299	Length:	561	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	137/543 - (25%)
Similarity:	224/543 - (41%)	Gaps:	94/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ICEENEFLANI------GLLSTTTMSRHQLKKPRK-------MVAAWQNDELFIKRPNFAPRIRI 68
            :.||.:..|..      |.||.|...::  ..|:|       :::|.:......||...     :
Frog    26 LAEEEDSSAKALVSLKEGGLSNTWNEKY--SSPQKTPNWKGGIISANETPYKLSKRSRL-----L 83

  Fly    69 SEKPEIQGRIKPGVASKRTENFTKKPSNISV-DVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLK 132
            |::.|.|...:   :.||....|..|...:| ..:..:||.:|            :|.||.|.||
Frog    84 SDEDERQLTTR---SPKRNPKTTVVPQKFNVTSTTPVKKASQK------------IGYRLRNLLK 133

  Fly   133 YLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAA 197
            ...:|:|...|:..|.:|||......|....:.|..|.|.:..:.|..|..:||.|||.||.|||
Frog   134 LPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSAA 198

  Fly   198 FIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGNSFEGIVNG 262
            |.|.||..||.:|:.:|.|||.|.   .:|.....:|..:||.|.....|::.|.| ..:|:..|
Frog   199 FFEEERSALEQKRQKIRLLQQRKV---ADVSQFKDLPDEIPLSLVIGTKVTARLRG-VHDGLFTG 259

  Fly   263 TVMGYDPQDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLS----------IIMRGNKSS-- 315
            .:...|.|:.||.|.|:|. .....::||.::.|:|....:|::          :.|...:||
Frog   260 QIDAVDTQNSTYRVTFDRT-GLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPPRMFMTPPRSSYT 323

  Fly   316 ---SVISE---------------SAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNE 362
               |.:.|               |:.||..|.  :..|.|..|.|:.|:..:|.:.:..|..||.
Frog   324 AIQSPVMESDTLLGQSPWKAKISSSDTETIGG--FPVEFLVQVTRLSKILMIKKEHIKLLRDMNT 386

  Fly   363 DFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLRILHDYLVEYQKQDEEE 427
            :.|..|...|          |.....||||:..::.|.::|.|:.:.|..:..|.  |:...::.
Frog   387 EAEKLKSYSS----------PISIEFQRRYATIVLDLEQLNKDLNKVLHKVQQYC--YELAPDQG 439

  Fly   428 ESKRGRPASEVYQKCRMQAEQDLKTAADEKFLK--IESDRTQEFVRNLHTILYLNGKL----GRE 486
            .....:|.| :.::|...|.|.::.|......:  ::::...|.:..|..|| |..|.    |..
Frog   440 LQPADQPTS-MRRRCEEDARQMVRRANTSSTGQPCVQNESLTELISRLTAIL-LQIKCLAEGGDL 502

  Fly   487 NSSNLETIIADLVTHMVDNIQPS 509
            ||...:: :.|.:..:...|.||
Frog   503 NSFEFKS-LTDSINDIKSTISPS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aly	NP_001261348.1	DIRP	147..252	CDD:284095	38/104 (37%)
lin9	XP_002941177.2	DIRP	146..250	CDD:368989	38/106 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4779
OMA	1	1.010	-	-		QHG48430
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005813
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21689
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.070