DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mts and PPP3CC

DIOPT Version :9

Sequence 1:	NP_001285724.1	Gene:	mts / 45959	FlyBaseID:	FBgn0004177	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001230903.1	Gene:	PPP3CC / 5533	HGNCID:	9316	Length:	521	Species:	Homo sapiens

Alignment Length:	286	Identity:	118/286 - (41%)
Similarity:	166/286 - (58%)	Gaps:	16/286 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDY 86
            :|.|.....:.:....||.:|..:.||..|:|||||:||||.|||:||.:||...:|.|||:|||
Human    51 RLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDY 115

  Fly    87 VDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD 151
            |||||:|:|.|..|.:||:.:.:.:.:||||||.|.:|..:.|..||..|| :..|:....:.||
Human   116 VDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKY-SEQVYDACMETFD 179

  Fly   152 YLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDP-DDRGGWGI---- 211
            .|||.||::.|..|:|||:||.|.|||.||.|||..|.|..||:|||||||| :|.|....
Human   180 CLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHY 244

  Fly   212 ---SPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDR------NVVTIFSAPNYCY 267
               :.||..|.:.......|...|.|..:.|||:....||......      :::||||||||..
Human   245 THNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLD 309

  Fly   268 RCGNQAALMELDDSLKFSFLQFDPAP 293
            ...|:||:::.:::: .:..||:.:|
Human   310 VYNNKAAVLKYENNV-MNIRQFNCSP 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mts	NP_001285724.1	MPP_PP2A_PP4_PP6	9..293	CDD:277360	117/284 (41%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	118/286 (41%)
		Catalytic. /evidence=ECO:0000305	52..343		118/285 (41%)
		PP2Ac	54..325	CDD:197547	114/272 (42%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	395..409
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	410..417
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	468..490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820