DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mts and PPEF2

DIOPT Version :9

Sequence 1:	NP_001285724.1	Gene:	mts / 45959	FlyBaseID:	FBgn0004177	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_006230.2	Gene:	PPEF2 / 5470	HGNCID:	9244	Length:	753	Species:	Homo sapiens

Alignment Length:	419	Identity:	109/419 - (26%)
Similarity:	163/419 - (38%)	Gaps:	136/419 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDKATTKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVK-C---PVTVCGDVHGQ 61
            :.|.||.     .:|......||....|..|..:.|:.|.:..|:..|. |   .:|||||:|||
Human   124 LPDHATA-----LVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQ 183

  Fly    62 FHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQ 125
            ..||:.:| :.|..||:.:|:|.||:||||..|||.:.:|.|..:.|.:...:.|||||...:..
Human   184 LDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNL 248

  Fly   126 VYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLS--PSIDSLDHI------ 180
            .|||..|.:.||  ....:.:...|:|.:|||..|:|.::..||||:|  ..::.||.|
Human   249 RYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIV 313

  Fly   181 --------------------------------------RAL---------------DRLQEVPHE 192
                                                  |:|               .|...:|..
Human   314 STMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCS 378

  Fly   193 GPM-------------------C-----------------------------------------D 197
            |.:                   |                                         |
Human   379 GSLDGRELSRQVRSSVELELERCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVD 443

  Fly   198 LLWSDPDDRGGWGISP-RGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFS 261
            :|||||..:.|...:. ||.|..||.|:::.......:..:.|:|:...|||.:||:|.|:||||
Human   444 ILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFS 508

  Fly   262 APNYCYRCG-NQAALMELDDSLKFSFLQF 289
            |.|| |..| |:.|.::|..:|....:|:
Human   509 ASNY-YEVGSNRGAYVKLGPALTPHIVQY 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mts	NP_001285724.1	MPP_PP2A_PP4_PP6	9..293	CDD:277360	106/411 (26%)
PPEF2	NP_006230.2	MPP_RdgC	122..537	CDD:277364	109/419 (26%)
		Catalytic	128..540		108/415 (26%)
		PP2Ac	141..540	CDD:197547	104/397 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..382		5/63 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..435		0/25 (0%)
		EFh	657..722	CDD:238008
		EF-hand_7	657..721	CDD:290234
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..753
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810