DRSC/TRiP Functional Genomics Resources

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Protein Alignment mts and Ppp3ca

DIOPT Version :9

Sequence 1:NP_001285724.1 Gene:mts / 45959 FlyBaseID:FBgn0004177 Length:309 Species:Drosophila melanogaster
Sequence 2:NP_032939.1 Gene:Ppp3ca / 19055 MGIID:107164 Length:521 Species:Mus musculus


Alignment Length:286 Identity:121/286 - (42%)
Similarity:171/286 - (59%) Gaps:16/286 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 QLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDY 86
            :|.|:....:..:...||.:|.|:.::..|||||||:||||.|||:||.:||...:|.|||:|||
Mouse    55 RLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDY 119

  Fly    87 VDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD 151
            |||||:|:|.|..|.|||:.|.:.:.:||||||.|.:|:.:.|..||..|| :..|:....|.||
Mouse   120 VDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY-SERVYDACMDAFD 183

  Fly   152 YLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDP-DDRGGWGI---- 211
            .|||.||::.|..|:||||||.|::||.||.|||.:|.|..|||||:||||| :|.|....    
Mouse   184 CLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHF 248

  Fly   212 ---SPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDR------NVVTIFSAPNYCY 267
               :.||..|.:.......|...|.|..:.|||:....||......      :::||||||||..
Mouse   249 THNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLD 313

  Fly   268 RCGNQAALMELDDSLKFSFLQFDPAP 293
            ...|:||:::.:::: .:..||:.:|
Mouse   314 VYNNKAAVLKYENNV-MNIRQFNCSP 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mtsNP_001285724.1 MPP_PP2A_PP4_PP6 9..293 CDD:277360 120/284 (42%)
Ppp3caNP_032939.1 MPP_PP2B 41..345 CDD:277361 121/286 (42%)
Catalytic. /evidence=ECO:0000305 56..340 121/285 (42%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209 327..336 2/9 (22%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871 341..369
Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871 392..406
Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871 407..414
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871 465..487
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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