DRSC/TRiP Functional Genomics Resources

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Protein Alignment spir and SPIRE2

DIOPT Version :10

Sequence 1:NP_724254.1 Gene:spir / 45931 FlyBaseID:FBgn0003475 Length:1020 Species:Drosophila melanogaster
Sequence 2:NP_115827.1 Gene:SPIRE2 / 84501 HGNCID:30623 Length:714 Species:Homo sapiens


Alignment Length:867 Identity:238/867 - (27%)
Similarity:365/867 - (42%) Gaps:226/867 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 LAMSSSAHPQQAGQARPLILQAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQ-FAGLYHQ 121
            :|.:.|.....||..||          .|.: ::|.::|.:::.||:|:||||:..| ..||.  
Human     1 MARAGSCGGAAAGAGRP----------EPWE-LSLEEVLKAYEQPLNEEQAWAVCFQGCRGLR-- 52

  Fly   122 VAVQAHTCAADYEAALPTGFELHFHRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIVDQPDHS 186
                    .:.......|| :|....||||....|:...|...:                     
Human    53 --------GSPGRRLRDTG-DLLLRGDGSVGAREPEAAEPATMV--------------------- 87

  Fly   187 ASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLPEDEECQVSQEL 251
                                       .||..|..:.:..|...:|.|||:.|.|.||.::|.:|
Human    88 ---------------------------VPLASSEAQTVQSLGFAIYRALDWGLDESEERELSPQL 125

  Fly   252 ENLFNFMTADETDDD---CIDEGIDEGDKRWDDESEEERNDTKELEHIIETCRNHIKTTLP---E 310
            |.|.:.|..::::|.   ..|||.  |....::|:|......:.....:..|.  .:.|.|   :
Human   126 ERLIDLMANNDSEDSGCGAADEGY--GGPEEEEEAEGVPRSVRTFAQAMRLCA--ARLTDPRGAQ 186

  Fly   311 NHYRAVCRALVTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVID 375
            .||:||||||..||:|||.||.:|...:...:||.:......|.:.||..||..||||.|||::.
Human   187 AHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETPRAELDSLGHTDWARLWVQLMR 251

  Fly   376 ELRRGVRLKKSNHER---TPIEYELTPYEILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILE 437
            ||||||:|||...:.   .|.|::|||:|:||.||||:.|:||||||:||||||||||||.:||:
Human   252 ELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILD 316

  Fly   438 FIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQITPP--------EAPTLRERVLP 494
            |||||||||:.|:|:|.|....:.|..|:::|.|::.:.|:.:...        ..|.:......
Human   317 FIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSG 381

  Fly   495 SANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPF 559
            .|.||                         :.|:.|.:.|                         
Human   382 DAKST-------------------------SCINLSVTDA------------------------- 396

  Fly   560 GGYMVPSQARQDCRETASLMRPR-RTMEPAKQVPPPEEPSFTKDEYHKF------YDTALESYDL 617
            ||               |..||| |.:..|..:...||.:.:::|....      .|.:...:||
Human   397 GG---------------SAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDL 446

  Fly   618 ATQCESRRASLRRHTIVGCQSNLDETH----SMPPT---------RPESRQSDDVSKETPKRSPA 669
                    |.||.....|.||   .||    :.||.         ||.||     .:.|...|.:
Human   447 --------AQLRSEVASGLQS---ATHPPGGTEPPRPRAGSAHVWRPGSR-----DQGTCPASVS 495

  Fly   670 EQTHP--SDEGSS----TSSLGPWNKSFMD-KQTWMERGD--DRLSVTLAEIVHIRSVMTKAELE 725
            :.:||  |:.|||    .:|:.|      | |..|:|...  :.|::|:.|::.:|.|:.|||:|
Human   496 DPSHPLLSNRGSSGDRPEASMTP------DAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEME 554

  Fly   726 GLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVL 790
            ....:..:...::|.::| .|.|.:|..|. |...|..|:|.||..|..||::||:.|.::|:..
Human   555 KFLQNKELFSSLKKGKIC-CCCRAKFPLFS-WPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYT 617

  Fly   791 I---SPSLLSSPASSSTPSPSHHAQQAHSSSTGNIMDDQFP---------KSLIERLLRSESD-- 841
            :   ||..:|  |:.:.|.......|:........:::.||         |.:........:|  
Human   618 LGFESPQRVS--AAKTAPIQRRDIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVV 680

  Fly   842 RKTRSTVGSAPSSPKHQRSNMS 863
            |.:|.:|....::|:..|...|
Human   681 RSSRKSVDVLNTTPRRSRQTQS 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spirNP_724254.1 KIND 90..327 CDD:214801 58/243 (24%)
WH2_Spire_1-2_r1 357..388 CDD:409208 20/30 (67%)
actin-binding sequence 383..386 CDD:409208 2/2 (100%)
WH2_Spire1_r2-like 394..425 CDD:409221 21/30 (70%)
actin-binding sequence 414..417 CDD:409221 2/2 (100%)
WH2_DmSpire_r3-like 427..452 CDD:409211 18/24 (75%)
WH2_DmSpire_r4 459..487 CDD:409212 5/35 (14%)
FYVE_SPIR 739..774 CDD:277287 13/34 (38%)
SPIRE2NP_115827.1 KIND 22..208 CDD:465129 62/248 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..162 7/27 (26%)
WH2_Spire_1-2_r1 233..264 CDD:409208 20/30 (67%)
actin-binding sequence 259..262 CDD:409208 2/2 (100%)
WH2_Spire2_r2 275..304 CDD:409222 20/28 (71%)
actin-binding sequence 293..296 CDD:409222 2/2 (100%)
WH2_Spire1-2_r3 307..329 CDD:409226 16/21 (76%)
WH2_Spire2_r4 339..360 CDD:409224 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 453..516 19/70 (27%)
Spir-box 534..554 8/19 (42%)
FYVE_SPIR2 566..680 CDD:277307 29/117 (25%)

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