DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spir and SPIRE1

DIOPT Version :9

Sequence 1:	NP_724254.1	Gene:	spir / 45931	FlyBaseID:	FBgn0003475	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_011524003.1	Gene:	SPIRE1 / 56907	HGNCID:	30622	Length:	814	Species:	Homo sapiens

Alignment Length:	896	Identity:	261/896 - (29%)
Similarity:	400/896 - (44%)	Gaps:	181/896 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 MSSSAHPQQAGQARPLIL---------QAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQF 115
            |:.:|.|...|:.|...:         .|..........::|.:||..:..|::|:||||:.:|.
Human     1 MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQC 65

  Fly   116 AGLYHQVAVQAHTCAADYEAALPTGFELHFHRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIV 180
            .|.....|.:.........||     ::...|||:|      .|.|
Human    66 CGSLRAAARRRQPRHRVRSAA-----QIRVWRDGAV------TLAP------------------- 100

  Fly   181 DQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVS--------HRKIISELAEIVYTALDY 237
                 :|..:|:                     ||.|..        ..::|..|..|:|.||||
Human   101 -----AADDAGE---------------------PPPVAGKLGYSQCMETEVIESLGIIIYKALDY 139

  Fly   238 NLPEDEECQVSQELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEER-NDTKELEHIIETCR 301
            .|.|:||.::|..||.|.:.|......|...|||.:..::...||.|:.: :..:....:::.|.
Human   140 GLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEGLGDEDEKRKISAIRSYRDVMKLCA 204

  Fly   302 NHIKT-TLPENHYRAVCRALVTETIELRVFLQQVLNNEAGAEKL--IKASESSATTQQELAKLGF 363
            .|:.| :...|||:||||||..||:||..||.::.:.:...:|:  ::.|:.|:|..:||...
Human   205 AHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTDLEELKNA-- 267

  Fly   364 NDWARFWVQVIDELRRGVRLKK---SNHERTPIEYELTPYEILMGDIRAKKYQLRKVMVNGDIPP 425
             |||||||||:.:||.||:|||   ..:...||||:|||||:||.|||.|:|.||||||||||||
Human   268 -DWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPP 331

  Fly   426 RVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPR---EQLMESIRKGKELKQITPPEAPT 487
            |:||.||.:||:||||||||...|.|:|.|   ..|.||   |:::|.|:..::|:.::|.|...
Human   332 RLKKSAHEIILDFIRSRPPLNPVSARKLKP---TPPRPRSLHERILEEIKAERKLRPVSPEEIRR 393

  Fly   488 LRERVLPSANS--------TLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFA 544
            .|..:.|.:.|        |...|.:.|:               |:|:.:...|:.|.::....:
Human   394 SRLAMRPLSMSYSFDLSDVTTPESTKNLV---------------ESSMVNGGLTSQTKENGLSTS 443

  Fly   545 EMHRCSQPKMPPYPFGGYMVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSF----TKDEYH 605
            :.....:.|:       ...|:.|..|..|:......:.|...:.....||||..    |:.:..
Human   444 QQVPAQRKKL-------LRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPP 501

  Fly   606 KFYDTALESYDLATQCESRRASLRRHTIVGCQSNLDETHSMPPTRPESR----QSDDVSKETPKR 666
            ||...:     ...|.|.|:...|||:|.. ::..:....:||:|..||    :...|...||.|
Human   502 KFLPIS-----STPQPERRQPPQRRHSIEK-ETPTNVRQFLPPSRQSSRSLVPRITSVWPRTPFR 560

  Fly   667 SPAEQT---------HPSDE---GSSTSSLGPWNKSFMDKQTWMERGD------DRLSVTLAEIV 713
             |...|         ||.:.   |.:.:......::|..:  |....:      :.|::|:.|::
Human   561 -PLFSTIQTASLLSSHPFEAAMFGVAGAMYYLCERAFTSR--WKSSKEEFCYPVECLALTVEEVM 622

  Fly   714 HIRSVMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRI 778
            |||.|:.|||||.......:...::|.::||.|...||||| .|...|:.|:|.||::|..|||:
Human   623 HIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFF-TWSYTCQFCKRPVCSQCCKKMRL 686

  Fly   779 PSEHFRNVPLVLISPSLL---SSPASSSTPSPSHH---AQQAHSSSTGNIMDD-----QFPKSLI 832
            ||:.:..:|:..:.||.|   .|...|..||.:||   ...|..||....||.     ||||.|:
Human   687 PSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELM 751

  Fly   833 E-----------RLLRSESDRKTRSTVGSAPSSPKHQRSN----MSTPGIS 868
            |           :...||....:|.::..|....:.:|..    ||:||.|
Human   752 EDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSPGPS 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spir	NP_724254.1	KIND	90..327	CDD:214801	63/246 (26%)
spir	NP_724254.1	FYVE_SPIR	739..774	CDD:277287	16/34 (47%)
SPIRE1	XP_011524003.1	KIND	40..236	CDD:293083	66/251 (26%)
SPIRE1	XP_011524003.1	FYVE_SPIR1	646..766	CDD:277306	42/120 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151877
Domainoid	1	1.000	221	1.000	Domainoid score	I2619
eggNOG	1	0.900	-	-		E1_28ID1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2799
Isobase	1	0.950	-	0	Normalized mean entropy	S8126
OMA	1	1.010	-	-		QHG45594
OrthoDB	1	1.010	-	-		D256673at33208
OrthoFinder	1	1.000	-	-		FOG0003625
OrthoInspector	1	1.000	-	-		otm41066
orthoMCL	1	0.900	-	-		OOG6_107798
Panther	1	1.100	-	-	LDO	PTHR21345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6306
SonicParanoid	1	1.000	-	-		X2497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750