DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spir and spire1a

DIOPT Version :9

Sequence 1:	NP_724254.1	Gene:	spir / 45931	FlyBaseID:	FBgn0003475	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_009292595.1	Gene:	spire1a / 557962	ZFINID:	ZDB-GENE-061013-119	Length:	781	Species:	Danio rerio

Alignment Length:	942	Identity:	261/942 - (27%)
Similarity:	393/942 - (41%)	Gaps:	267/942 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LAMSSSAHPQQAGQARPLILQAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQFAGLYHQV 122
            :.:|.||.......|||..:..  .|:..|:.:.|.:||..:..|::|:||||:.:|......|.
Zfish     6 MLISPSALQDPGDGARPEDIAM--DCTDGEEELCLEEILTLYSQPINEEQAWAVCYQCCRWLTQK 68

  Fly   123 AVQAHTCAADYEAALPTG-----FELHFHRDGSVHF---SGPDQLTPKEQLQQEQIPLPPQHDVI 179
            ..:..|      ...|.|     .::...:||:|..   |.||:.||.
Zfish    69 HRRKET------GVSPPGRIAGPGDVRIRKDGNVKLYQPSNPDKHTPP----------------- 110

  Fly   180 VDQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLPEDEE 244
                        .||:                          :||..|..::|.||||.|.|.||
Zfish   111 ------------SSSI--------------------------EIIESLGIMIYKALDYGLKEHEE 137

  Fly   245 CQVSQELENLFNFMT--ADETDDDCIDEGIDEGDKRWDDESEEER---NDTKELEHIIETCRNHI 304
            .::|..||.|.:.||  || |:.||.|||.:..::  :||.|||.   ::.:....||..|.:|:
Zfish   138 RELSPPLEQLIDLMTNMAD-TETDCPDEGYEATEE--EDEGEEENAEVSNVRGYRDIISLCLSHL 199

  Fly   305 KTTLPE---NHYRAVCRALVTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAKLGFNDW 366
            .:  |.   |||:||||||..||.|||.||:::   ::..|.|.|....:....::|.:|...||
Zfish   200 PS--PSDAPNHYQAVCRALYAETKELRTFLEKI---KSAKENLRKMEGETEEPVRDLNELQNADW 259

  Fly   367 ARFWVQVIDELRRGVRLKK-SNHERTP--IEYELTPYEILMGDIRAKKYQLRKVMVNGDIPPRVK 428
            |||||||:.:||.||:||| ...:..|  |||:|||||:||.|||:|:|:|||||||||||||:|
Zfish   260 ARFWVQVMRDLRHGVKLKKVQERQYNPLAIEYQLTPYEMLMDDIRSKRYKLRKVMVNGDIPPRLK 324

  Fly   429 KDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQITP----------- 482
            |.||.:|||||||||||...|.|:|.|.....|:..|:::|.||..::|:.::|
Zfish   325 KSAHEIILEFIRSRPPLNPVSARKLKPHAPQPPTLHERILEEIRSERKLRPVSPDMIRRSRLVMR 389

  Fly   483 -----------------------------PEAP-TLRERVLPSANSTL-SRS------------- 503
                                         |:.| .|....|..||.|. :||
Zfish   390 PLSMSVSFDSSGAGKSISTPQDLFRSSDIPDGPRKLAISTLSLANGTSPARSPVNGVAGGHSLSQ 454

  Fly   504 RQRLIK------VDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPFGGY 562
            |:||:|      :|.|..:::......:| |||.||:......|...      ..|.||..|
Zfish   455 RKRLLKAPTLAELDSSDSEEEQSTRKSDS-SSSISTSLVEDTSPESV------MGKKPPPQF--- 509

  Fly   563 MVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSFTKDEYHKFYDTALESYDLATQCESRRAS 627
                                   .|....|.|::                           |.|.
Zfish   510 -----------------------LPISSTPQPDK---------------------------RIAP 524

  Fly   628 LRRHTIVGCQSNLDETHSMPPTRPESR--QSDDVSKETPKRSPAEQTHPSDEGSSTSSLGPWNKS 690
            .|||:|.. ::..:..|.:||:|..|:  .|.|           .:.|....|.:.....|
Zfish   525 QRRHSIEK-EAPTNIRHFLPPSRQNSKSLMSSD-----------GKAHALGSGHAEEFCFP---- 573

  Fly   691 FMDKQTWMERGDDRLSVTLAEIVHIRSVMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFG 755
                       .:.|::|:.|::|||.|:.|||||.......:...::|.::||.|...:||.|
Zfish   574 -----------VECLTLTVEEVMHIRQVLVKAELEKFQQYKDIYNALKKGKLCFSCRSKKFSLF- 626

  Fly   756 PWGIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVLISPSLL--SSPASSSTPSPSHHAQQAHSSS 818
            .|...|:.|:|.||::|..||::||:...::|:..:.||:|  ..|.:||.|:....:..:|.
Zfish   627 TWSYTCQFCKRPVCSQCCKKMKLPSKPHASLPISSLGPSILPKKEPGASSAPTDKTSSTSSHK-- 689

  Fly   819 TGNIMDDQFPKSLIERLLRSESDRKTRSTVGSAPSSPKHQRSNMSTPGISV------------GP 871
                      |:.::|.|...|....||:.......|:....:.||..:.|            ..
Zfish   690 ----------KNSLQRSLSRSSKHGDRSSSKDELELPEQFTEDWSTMEVCVDCKKFINDIISNSR 744

  Fly   872 GASSSSAAATGQAVEALHDQATMSSSYSAAMR 903
            ...|:..|...:...:::..:|.||:|....|
Zfish   745 RNLSTKRARLHRRTHSVYSSSTSSSNYKPTER 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spir	NP_724254.1	KIND	90..327	CDD:214801	71/252 (28%)
spir	NP_724254.1	FYVE_SPIR	739..774	CDD:277287	14/34 (41%)
spire1a	XP_009292595.1	KIND	45..228	CDD:293083	72/248 (29%)
spire1a	XP_009292595.1	FYVE_SPIR1	609..744	CDD:277306	37/147 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586454
Domainoid	1	1.000	229	1.000	Domainoid score	I2406
eggNOG	1	0.900	-	-		E1_28ID1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2819
OMA	1	1.010	-	-		QHG45594
OrthoDB	1	1.010	-	-		D256673at33208
OrthoFinder	1	1.000	-	-		FOG0003625
OrthoInspector	1	1.000	-	-		otm24312
orthoMCL	1	0.900	-	-		OOG6_107798
Panther	1	1.100	-	-	LDO	PTHR21345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6306
SonicParanoid	1	1.000	-	-		X2497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800