Protein Alignment spir and spire2

DIOPT Version :9

• Sequence 1: NP_724254.1
• Gene: spir / 45931
• FlyBaseID: FBgn0003475
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001007343.2
• Gene: spire2 / 492470
• ZFINID: ZDB-GENE-041114-29
• Length: 730
• Species: Danio rerio
• Alignment Length: 854
• Identity: 223/854 - (26%)
• Similarity: 356/854 - (41%)
• Gaps: 204/854 - (23%)

  Fly    90 VTLHDILDSFKAPLSEDQAWALIHQFAGLYHQVAVQAHTCAADYEAALPTGFELHFHRDGSVHFS 154
            ::|..:|.|::.|::|:||||:..|..|.......|.|....:.:...|....|  ||||.|
Zfish    21 LSLEKVLKSYEQPINEEQAWAVCFQCCGDLRAPRPQPHPRHPELQIRDPASIIL--HRDGRV--- 80

  Fly   155 GPDQLTPKEQLQQEQIPLPPQHDVIVDQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVS 219
                    ..|.|.           .|..:....|:.|.
Zfish    81 --------TALLQS-----------CDDSNAGCESAADG-------------------------- 100

  Fly   220 HRKIISELAEIVYTALDYNLPEDEECQVSQELENLFNFMTADETDDDC-------IDEGIDEGDK 277
              |::..|...:|.|||:.|.:.||.::|.:||.|..||..   ..||       .:...|||..
Zfish   101 --KLVQSLGVAIYRALDWGLDDSEERELSPQLEQLIEFMVG---GPDCGQSKHCGSNAAKDEGYS 160

  Fly   278 RWDDESEEERND------TKELEHIIETCRNHI-KTTLPENHYRAVCRALVTETIELRVFLQQVL 335
            ..|:|.|||..:      ...::.::..|.:.: ...|...||:||||||..||:||:.||.::.
Zfish   161 GQDEEEEEEEEEEGAGRGIHTVQQVMTMCASRLANPVLAPEHYQAVCRALFLETLELQTFLSRIR 225

  Fly   336 NNEAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVIDELRRGVRLKKSNHE---RTPIEYEL 397
            :.:...:| |:..|....:..||..|...||||.|||::.|||:||:|||...:   ..|.|:.|
Zfish   226 DAKEMLKK-IRTEEPQEDSAAELDALQHTDWARLWVQLMKELRQGVKLKKVEEQPFNPLPTEFSL 289

  Fly   398 TPYEILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPS 462
            ||:|:||.|||.:||:||||:|:|:||..||::||.:||:|||||||||..|:|.|.||.....|
Zfish   290 TPFEMLMQDIRLRKYKLRKVVVDGNIPTCVKRNAHELILDFIRSRPPLKPVSERSLPPPPQRPQS 354

  Fly   463 PREQLMESIRKGKELKQITPPEA-------PTLRERVLPSANST--------------LSRSRQR 506
            ..::::..||:..:|:.:..|.:       |.|.........||              .||.|..
Zfish   355 LHDRVLAEIRQDHKLRPVELPSSKRSFGSLPCLAHTCQCDIKSTSCIDLSVTGAGSRPSSRIRVL 419

  Fly   507 LIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPFGGYMVPSQARQD 571
            |.....::.::.:||.||:|              |...:|.|......|
Zfish   420 LKAPTLAEMEEMNLFEDEDS--------------PDGVDMRRVESSPTP---------------- 454

  Fly   572 CRETASLMRPRRTMEPAKQVPPPEEPSFTKDEYHK-----FYDTALESYDLATQCESRRASLRRH 631
                  |.|.|               ||::.:..:     ..|:...|...|.:.|..|:    |
Zfish   455 ------LKRDR---------------SFSEHDLDELRGEMMSDSPQHSGVAALRAERPRS----H 494

  Fly   632 TIVGC-QSNLDETHSMPPTRPESRQSDDVSKETPKRSPAEQTHPSDEGSSTSSLGPWNKSFMDKQ 695
            |:.|. |::.........:...|..|||.|.:.|             |..::|.|      :.:.
Zfish   495 TLTGVYQASFPGFERRSASTCRSLSSDDRSSDDP-------------GGDSASHG------LSRH 540

  Fly   696 TWME---RGDDRLSVTLAEIVHIRSVMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPW 757
            .|||   ...:.|::|:.|::::|.::.|||:|....:..:..:::|.::| .|.|.:|..|. |
Zfish   541 QWMEEFCHPVETLALTVDEVINVRRILVKAEMEKYMQNKELFSNLKKGKIC-CCCRVKFPLFS-W 603

  Fly   758 GIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVLI----SPSLLSSPASSSTPSPSHHAQQ---AH 815
            ...|.||:|:||:.|..||:||.:...::|:..:    |.....|....|..|.|.|:.:   .|
Zfish   604 PSTCLLCKRSVCSSCSAKMKIPYKKMAHIPVYTVGFHSSAKSHKSEVYKSLCSLSRHSVEEEFPH 668

  Fly   816 SSSTG-NIMD-----DQFPKSLIERLLRSESDRKTRSTVGSAPSSPKHQRSNMSTPGISVGPGAS 874
            ..:.| |:.|     .:|...:|      .|.|::...:.:.|      :.|..||.....|.:.
Zfish   669 LYAAGCNLRDVCSDCTRFVADVI------SSSRRSLDIINNTP------KRNKRTPATRSQPASH 721

  Fly   875 SSSAAATGQ 883
            ..::..|.:
Zfish   722 PHASCRTSK 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spir	NP_724254.1	KIND	90..327	CDD:214801	62/250 (25%)
		FYVE_SPIR	739..774	CDD:277287	14/34 (41%)
spire2	NP_001007343.2	KIND	21..222	CDD:318636	65/255 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..462		11/76 (14%)
		Spir-box	553..573		7/19 (37%)
		FYVE_like_SF	585..691	CDD:333710	30/107 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586455
Domainoid	1	1.000	84	1.000	Domainoid score	I8203
eggNOG	1	0.900	-	-		E1_28ID1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2819
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256673at33208
OrthoFinder	1	1.000	-	-		FOG0003625
OrthoInspector	1	1.000	-	-		otm24312
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7172
SonicParanoid	1	1.000	-	-		X2497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890