DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spir and Spire2

DIOPT Version :9

Sequence 1:	NP_724254.1	Gene:	spir / 45931	FlyBaseID:	FBgn0003475	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_001121010.2	Gene:	Spire2 / 307925	RGDID:	1305837	Length:	714	Species:	Rattus norvegicus

Alignment Length:	878	Identity:	242/878 - (27%)
Similarity:	366/878 - (41%)	Gaps:	261/878 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SAHPQQA-GQARPLILQAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQ-FAGLYHQVAVQ 125
            :|.|::| |.|||          .|.: ::|.::|..::.|::|:||||:..| ..||..:
  Rat     9 AAAPERAGGAARP----------EPWE-LSLEEVLKVYEQPINEEQAWAVCFQGCRGLRGE---- 58

  Fly   126 AHTCAADYEAALPTGF-------ELHFHRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIVDQP 183
                        |.|.       ::...|||||                 ...|.|:...:|..|
  Rat    59 ------------PGGVRRIRDTADILLRRDGSV-----------------GARLEPEPSTMVVPP 94

  Fly   184 DHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLPEDEECQVS 248
            .:|.:                                 :::..|...:|.|||:.|.|:||.::|
  Rat    95 ANSEA---------------------------------QMVQSLGFAIYRALDWGLDENEERELS 126

  Fly   249 QELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEERND-----TKELEHIIETCRNHIKTTL 308
            .:||.|.:.|    .:.||.|......|:.:....|||..:     .:.....:..|.:.:  |.
  Rat   127 PQLERLIDLM----ANSDCEDSSCGAADEGYGGPEEEEEAEGGPRAVRTFAQAMRLCASRL--TD 185

  Fly   309 P---ENHYRAVCRALVTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAK---LGFNDWA 367
            |   :.||:||||||..||:|||.||.:|  .|| .|.|.|..|.....::.||:   ||..|||
  Rat   186 PHGAQAHYQAVCRALFVETLELRAFLARV--REA-KEMLQKLGEDEPRVEKPLAELDHLGHTDWA 247

  Fly   368 RFWVQVIDELRRGVRLKKSNHER---TPIEYELTPYEILMGDIRAKKYQLRKVMVNGDIPPRVKK 429
            |.|||::.|||.||:|||...:.   .|.|::|||:|:||.||||:.|:||||||:|||||||||
  Rat   248 RLWVQLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKK 312

  Fly   430 DAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQITPPEAPTLRER--- 491
            |||.:||:|||||||||:.|:|:|.|....:.:..|:::|.|::.:.|:   |..|..|..|
  Rat   313 DAHELILDFIRSRPPLKQVSERRLRPVPQKQRTLHEKILEEIKQERRLR---PVGAEHLGARGFG 374

  Fly   492 VLP---------------------SANSTLSRSRQR-LIKVDFSKFQDDDLFYDENSISSSHSTA 534
            .||                     .|.|...|.|.| |:|.
  Rat   375 SLPCILNACSGDIKSTSCINLSVTDAGSGSQRPRPRVLLKA------------------------ 415

  Fly   535 ATHQHHPHFAEMHRCSQPKMPPYPFGGYMVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSF 599
                  |..|||...|.|:....|             |.|.| |.|.|               ||
  Rat   416 ------PTLAEMEEMSTPEEEESP-------------CGEVA-LKRDR---------------SF 445

  Fly   600 TKDEYHKFYDTALESYDLATQCESRRASLRRHTIVGCQSNLDETHSMPP--TRPESRQSDDVSKE 662
            ::             :||| |..|...|       |.||     .:.||  |.|...::..:...
  Rat   446 SE-------------HDLA-QLRSEMGS-------GLQS-----ATQPPGGTEPPRVRAGSMHSW 484

  Fly   663 TPKR--------SPAEQTHPSDEGSSTSSLGPWNKSFMDKQTWMERGD--DRLSVTLAEIVHIRS 717
            .|..        |...|.|||:..|:.   ||...:...:..|:|...  :.|::|:.|:|.:|.
  Rat   485 RPSTRDQGLCSVSGQSQPHPSNLSSAD---GPEASAPDARHLWLEFSHPVESLALTVEEVVDVRR 546

  Fly   718 VMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEH 782
            |:.|||:|....|..:...:::.::| .|.||:|..|. |...|..|:|.||..|..||::||:.
  Rat   547 VLVKAEMEKFLQDKELFSSLKRGKIC-CCCRTKFPLFS-WPPTCLFCKRAVCTSCSVKMKMPSKK 609

  Fly   783 FRNVPLVLIS-PSLLSSPASSSTPSPSHHAQQAHSSSTGNIMDDQFP----------------KS 830
            ..::|:..:. .||...|.:.::|:....|.|.........::::||                .|
  Rat   610 HGHIPVYTLGFESLQRVPTTKASPALRRDAFQCLQGPKWRSVEEEFPHIYAHGCVLKDVCSDCTS 674

  Fly   831 LIERLLRSESDRKTRSTVGSAPSSPKHQRSNMS 863
            .:..::.|     :|.:|....::|:..|...|
  Rat   675 FVADVVCS-----SRKSVDVLNATPRRSRQTQS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spir	NP_724254.1	KIND	90..327	CDD:214801	57/252 (23%)
spir	NP_724254.1	FYVE_SPIR	739..774	CDD:277287	13/34 (38%)
Spire2	NP_001121010.2	KIND	26..212	CDD:406789	61/257 (24%)
		WH2_Spire_1-2_r1	237..268	CDD:409208	17/30 (57%)
		WH2_Spire2_r2	279..308	CDD:409222	20/28 (71%)
		WH2_Spire1-2_r3	311..333	CDD:409226	16/21 (76%)
		WH2_Spire2_r4	343..364	CDD:409224	5/23 (22%)
		FYVE_like_SF	566..680	CDD:333710	27/115 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345396
Domainoid	1	1.000	215	1.000	Domainoid score	I2632
eggNOG	1	0.900	-	-		E1_28ID1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2459
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256673at33208
OrthoFinder	1	1.000	-	-		FOG0003625
OrthoInspector	1	1.000	-	-		otm45205
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21345
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860