DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spir and Spire2

DIOPT Version :9

Sequence 1:	NP_724254.1	Gene:	spir / 45931	FlyBaseID:	FBgn0003475	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_758491.1	Gene:	Spire2 / 234857	MGIID:	2446256	Length:	718	Species:	Mus musculus

Alignment Length:	877	Identity:	242/877 - (27%)
Similarity:	367/877 - (41%)	Gaps:	255/877 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SAHPQQA-GQARPLILQAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQ-FAGLYHQVAVQ 125
            :|.|::| |.|||          .|.: ::|.::|..::.|::|:||||:..| ..||..:
Mouse     9 AAAPERAGGAARP----------EPWE-LSLEEVLKVYEQPINEEQAWAVCFQGCRGLRGE---- 58

  Fly   126 AHTCAADYEAALPTGF-------ELHFHRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIVDQP 183
                        |.|.       ::...|||||                 ...|.|:...:|..|
Mouse    59 ------------PGGVRRIRDTADILLRRDGSV-----------------GARLEPEPTTMVVPP 94

  Fly   184 DHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLPEDEECQVS 248
               |||..                              :::..|...:|.|||:.|.|:||.::|
Mouse    95 ---ASSEA------------------------------QMVQSLGFAIYRALDWGLDENEERELS 126

  Fly   249 QELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEERND-----TKELEHIIETCRNHIKTTL 308
            .:||.|.:.|    .:.||.|......|:.:....|||..:     .:.....:..|.  ::.|.
Mouse   127 PQLERLIDLM----ANSDCEDSSCGAADEGYVGPEEEEEAEGGPRAVRTFAQAMRLCA--LRLTD 185

  Fly   309 P---ENHYRAVCRALVTETIELRVFLQQVLNNEAGAEKLIKASESSATTQ--QELAKLGFNDWAR 368
            |   :.||:||||||..||:|||.||.:|  .|| .|.|.|..|.....:  .||..||..||||
Mouse   186 PHGAQAHYQAVCRALFVETLELRAFLARV--REA-KEMLKKLGEEEPREKPLAELDHLGHTDWAR 247

  Fly   369 FWVQVIDELRRGVRLKKSNHER---TPIEYELTPYEILMGDIRAKKYQLRKVMVNGDIPPRVKKD 430
            .|||::.|||.||:|||...:.   .|.|::|||:|:||.||||:.|:||||||:||||||||||
Mouse   248 LWVQLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKD 312

  Fly   431 AHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQITPPEAPTLRERVLPS 495
            ||.:||:|||||||||:.|:|||.|....:.:..|:::|.|::.:.|:.:
Mouse   313 AHELILDFIRSRPPLKQVSERQLRPVPQKQRTLHEKILEEIKQERRLRPV--------------- 362

  Fly   496 ANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAE----MHRCSQPKMPP 556
                                                  .|.|.....|..    ::.||
Mouse   363 --------------------------------------GAQHLGGRGFGSLPCILNACS------ 383

  Fly   557 YPFGGYMVPSQARQDCRETAS-LMRPR-RTMEPAKQVPPPEEPSFTKDEYHKFYDTALE------ 613
               |.....|.......:|.| ..||| |.:..|..:...||.:.:::|.....:.||:
Mouse   384 ---GDIKSTSCINLSVTDTGSGSQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVALKRDRSFS 445

  Fly   614 SYDLATQCESRRASLRRHTIVGCQSNLDETHSMPPTRPESRQSDDVSKETPKRSPAEQTH---PS 675
            .:||| |..|..||       |.||     .:.||...|           |.|:.|...|   ||
Mouse   446 EHDLA-QLRSEMAS-------GLQS-----AAQPPGGTE-----------PPRARAGSMHSWRPS 486

  Fly   676 --DEG-----------------SSTSSL-GPWNKSFMDKQTWMERGD--DRLSVTLAEIVHIRSV 718
              |:|                 ||.||: ||...|...:..|:|...  :.|::|:.|:|.:|.|
Mouse   487 SRDQGFCPVSGQSQPLPSSALPSSLSSVDGPEAASPDTRHLWLEFSHPVESLALTVEEVVDVRRV 551

  Fly   719 MTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEHF 783
            :.|||:|....|..:...:::.::| .|.|.:|..|. |...|..|:|.||..|..||::||:.:
Mouse   552 LVKAEMERFLQDKELFSSLKRGKIC-CCCRAKFPLFS-WPPTCLFCKRAVCTSCSVKMKMPSKKY 614

  Fly   784 RNVPLVLIS-PSLLSSPASSSTPSPSHHAQQAHSSSTGNIMDDQFP----------------KSL 831
            .::|:..:. .||...|.:.:||:....|.|:........::::||                .|.
Mouse   615 GHIPVYTLGFESLQRVPTTKATPTLRRDAFQSLQGPKWRSVEEEFPHIYAHGCVLKDVCSDCTSF 679

  Fly   832 IERLLRSESDRKTRSTVGSAPSSPKHQRSNMS 863
            :..::.|     :|.:|....::|:..|...|
Mouse   680 VADVVCS-----SRKSVDVLNATPRRSRQTQS 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spir	NP_724254.1	KIND	90..327	CDD:214801	59/252 (23%)
spir	NP_724254.1	FYVE_SPIR	739..774	CDD:277287	12/34 (35%)
Spire2	NP_758491.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		7/22 (32%)
		KIND	26..212	CDD:293083	63/257 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..166		5/22 (23%)
		DUF505	<174..>351	CDD:302912	92/181 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..434		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..518		21/84 (25%)
		Spir-box	538..558		9/19 (47%)
		FYVE_SPIR2	570..684	CDD:277307	27/115 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842001
Domainoid	1	1.000	212	1.000	Domainoid score	I2771
eggNOG	1	0.900	-	-		E1_28ID1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3188
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003625
OrthoInspector	1	1.000	-	-		otm43137
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7172
SonicParanoid	1	1.000	-	-		X2497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.880