DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spir and LOC100485551

DIOPT Version :9

Sequence 1:	NP_724254.1	Gene:	spir / 45931	FlyBaseID:	FBgn0003475	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_004918775.1	Gene:	LOC100485551 / 100485551	-ID:	-	Length:	644	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	190/740 - (25%)
Similarity:	283/740 - (38%)	Gaps:	214/740 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SSPEQC--VTLHDILDSFKAPLSEDQAWALIHQFAGLYHQVAVQAHTCAADYEAALPTGFE-LHF 145
            |.|..|  |||.:||..:..|:||:|||||.:|......|:...|.      :.....|.| :|.
Frog     5 SPPGGCSKVTLKEILQGYGQPISEEQAWALCYQCCTKLKQMLWGAK------QVPFVRGVEHIHL 63

  Fly   146 HRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIVDQPDHSASSSGDSSVINRAFDNSNHHHHHQ 210
            |:||:..|:     ..|||                      ..:...|..||:|
Frog    64 HQDGTASFA-----VSKEQ----------------------RGARNGSQDINQA----------- 90

  Fly   211 HHHPPLVVSHRKIISELAEIVYTALDYNLPEDEECQVSQELENLFNFMTADETDDDCIDEGIDEG 275
                     .||||..|.:::|||||:.|..|.|..:|:.|:.|...|..  .....||..:
Frog    91 ---------ERKIIEHLGQVIYTALDWGLTSDMERVLSEPLDKLLYSMLG--LHAVAIDYSL--- 141

  Fly   276 DKRWDDESEEERNDTKELEHIIETCRNHIKTTLPEN---HYRAVCRALVTETIELRVFLQQVLNN 337
                      .......|:.||:.|.:.:.|  |..   ||||||:.|..|..|   |...:|..
Frog   142 ----------HFQCPIMLKDIIKQCADRLFT--PSEAYIHYRAVCQVLFAEHKE---FCNLLLTI 191

  Fly   338 EAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVIDELRRGVRLKKS---NHERTPIEYELTP 399
            |...:.|.|........:.  |.:.:::|...|..||.|||.|:||:.|   ::...|.||||||
Frog   192 ERSKQSLRKLEAEDILDKD--AIILYDNWGNLWSNVIKELRLGIRLRNSKDRSYVGLPAEYELTP 254

  Fly   400 YEILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPR 464
            ||:||.|||||:|.||:|..:.  ..::.:.....|::|||.: ||:.||:|:|......|||..
Frog   255 YELLMNDIRAKRYTLREVKESQ--KRKMSESVENFIMDFIRLQ-PLRPASERKLKEKSQEEPSLH 316

  Fly   465 EQLMESIRKGKELKQITPPEAPTLRERVLPSANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISS 529
            |.||..|:.||:|:                   :|..|.|..|        ||||      |:||
Frog   317 ELLMTEIKSGKKLR-------------------ATRRRKRNCL--------QDDD------SLSS 348

  Fly   530 SHSTAATHQHHPHFAEMHRCSQPKMPPYPFGGYMVPSQARQDCRETASLMRPRRTMEPAKQVPPP 594
            .           .|::    |...:.|..:         |..|               ::..|
Frog   349 Q-----------SFSQ----SDDSLSPLDY---------RMSC---------------SRSTP-- 372

  Fly   595 EEPSFTKDEYHKFYDTALESYDLATQCESRRASLRRHTIVGCQSNLDETHSMPPTRPESRQSDDV 659
                              ::.||.:. ||..:.::    :..||:....:|     .:|:.||..
Frog   373 ------------------QASDLGSN-ESDVSDVK----ISWQSDFSSENS-----SDSKFSDLT 409

  Fly   660 SKETP--------------KRSP---AEQTHPSDEGSSTSSLGPWNKSFMDKQTWMERGDDRLSV 707
            |..|.              |.|.   |:....|....|:|...|..|.:.|......:  .|...
Frog   410 SSSTDLMFVPVLTSSQVDLKNSSFLNADMLKYSSHKRSSSYESPLQKKYTDHNCRYPK--IRPIP 472

  Fly   708 TLAEIVHIRSVMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKC 772
            |:||:|..|..:.|||:    .|..........|:||.|.:.|..|  .|...||:|:|.:|.:|
Frog   473 TIAELVPTRRDIVKAEM----ADFLQNYGFSGSRICFCCHKKRLFF--TWPYTCKICERVICPEC 531

  Fly   773 YTKMRIPSEHFRNVPLVLISPSLLS 797
            ..:|.:|.:...::||......:|:
Frog   532 CVEMLMPFKQCMHLPLSFFKTLVLT 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spir	NP_724254.1	KIND	90..327	CDD:214801	63/240 (26%)
spir	NP_724254.1	FYVE_SPIR	739..774	CDD:277287	13/34 (38%)
LOC100485551	XP_004918775.1	PKc_like	13..188	CDD:389743	65/247 (26%)
LOC100485551	XP_004918775.1	FYVE_SPIR	502..534	CDD:277287	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256673at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010