DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MUSK and Ret

DIOPT Version :10

Sequence 1:XP_005252051.1 Gene:MUSK / 4593 HGNCID:7525 Length:879 Species:Homo sapiens
Sequence 2:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster


Alignment Length:800 Identity:207/800 - (25%)
Similarity:313/800 - (39%) Gaps:157/800 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   146 GNPKPSVSW---IKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLE 207
            |.|...||.   ...:...||......||:..|.|  |.:.||     ::..:....:..:.||.
  Fly   327 GRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTI--VSRVDA-----MSATANVCYHINLSKLH 384

Human   208 VEEESEPEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVK 272
             |.|.|..|...:.||..|..||......|      ....:..||:.:.::.:...|.    :..
  Fly   385 -ESEQELPQALPLRARQHRIFESEEFNGDS------AGRSLSPPTVDYDKDVSVYRSA----ASN 438

Human   273 DRVI--DSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVC 335
            .||:  ||.|.|...:...:..:.     :|.......:|..|.....||               
  Fly   439 FRVVQPDSFLDLMRLRSIRFDIVE-----DKLGAFGITSTSGIVFVKNPQ--------------- 483

Human   336 NAVL--AKDALVFLNTSYADPEEAQEL------LVH----TAWNELKVVSPVCRPAAEALLCNHI 388
              ||  |.:.:.|||.::.|.:....:      |||    ....||||.|       .:..|..|
  Fly   484 --VLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKS-------RSQTCAQI 539

Human   389 FQECSPGVVPTPIPICREYC-LAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHW 452
            ..:..          |..|| ||.....|  :|...........|.|     .|||....|....
  Fly   540 KYQSQ----------CVRYCGLATGGGSC--QWRGSNSAMFGTRYGS-----CVPESRYCPDHVC 587

Human   453 DP-------------TACARL--PH-LDYNKEN--------------------LKTFPPM----- 476
            ||             |...|:  || .:.||..                    |...|.|     
  Fly   588 DPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRK 652

Human   477 ----TSSKPSVDI-----PNLPSSSSSSFSVSPTYSM----TVIISIMSSFAIFVLLTITTLYCC 528
                |.::|.:.:     ||.|........|......    :.:..:::...:||||.:..|...
  Fly   653 RKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQ 717

Human   529 RRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLS----LEYPRNNIEYVR 589
            |:..|.:..|:.....:...||.....|       :..|||....:..|    .|:||..::...
  Fly   718 RKMLQRRLGKQSMTTSSKQALPESGGGD-------FALMPLQSGFRFESGDAKWEFPREKLQLDT 775

Human   590 DIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGV 654
            .:|||.||:|.:..|..:......|.|||||||:.:::........|..|:.|..:||::||||.
  Fly   776 VLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGA 840

Human   655 CAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQV 719
            |...:...|:.||..||.|..:||.........:..:|          |..|::....|..|.|:
  Fly   841 CTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFAD----------GVEPVNVKMVLTFAWQI 895

Human   720 AAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESI 784
            ..|||||||.|.||||||.||.|:.:..:.||:||||:|::|..|.|.....|.:|::||.|||:
  Fly   896 CKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESL 960

Human   785 FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCW 849
            ..:.||::||||::||:.||:.:.|..||.|:|.:.:...::.|..:..||||...:|:::|.||
  Fly   961 ADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCW 1025

Human   850 SKLPADRPSFTSIHRILERM 869
            :..|..||||..:....|::
  Fly  1026 ADEPNGRPSFKFLASEFEKL 1045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MUSKXP_005252051.1 IgI_1_MuSK 28..117 CDD:409562
Ig strand A 28..31 CDD:409562
Ig strand A' 35..39 CDD:409562
Ig strand B 45..52 CDD:409562
Ig strand C 58..63 CDD:409562
Ig strand C' 65..67 CDD:409562
Ig strand D 75..78 CDD:409562
Ig strand E 82..88 CDD:409562
Ig strand F 95..102 CDD:409562
Ig strand G 109..117 CDD:409562
Ig 122..206 CDD:472250 13/62 (21%)
Ig strand B 138..142 CDD:409353
Ig strand C 151..155 CDD:409353 2/6 (33%)
Ig strand E 173..177 CDD:409353 1/3 (33%)
Ig strand F 187..192 CDD:409353 0/4 (0%)
Ig strand G 201..204 CDD:409353 0/2 (0%)
Ig_3 228..296 CDD:464046 12/69 (17%)
CRD_FZ 325..467 CDD:470581 36/170 (21%)
PTKc_Musk 579..868 CDD:133181 105/288 (36%)
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 103/285 (36%)
Blue background indicates that the domain is not in the aligned region.

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