Protein Alignment MUSK and Tie

DIOPT Version :10

• Sequence 1: XP_005252051.1
• Gene: MUSK / 4593
• HGNCID: 7525
• Length: 879
• Species: Homo sapiens
• Sequence 2: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Alignment Length: 94
• Identity: 17/94 - (18%)
• Similarity: 26/94 - (27%)
• Gaps: 34/94 - (36%)

Human   106 PSSRWALWSVGGEVHVALQI----------------------------PFNVSSLVAMYSTALLS 142
            |.:.:|.|...|..|..:::                            .|..|.|:.......|.
  Fly    26 PINGYAYWLGLGVYHSGVEVHGIEYAYGAHEYPSTGIFEGEPKQCEGFTFRKSILIGKTDLGPLE 90

Human   143 LDHYIERALPRTYMASVY-----NTRHVC 166
            :...:|: |...|..|.|     |..|.|
  Fly    91 VRATMEQ-LADNYKGSSYNLITKNCNHFC 118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	IgI_1_MuSK	28..117	CDD:409562	3/10 (30%)
		Ig strand A	28..31	CDD:409562
		Ig strand A'	35..39	CDD:409562
		Ig strand B	45..52	CDD:409562
		Ig strand C	58..63	CDD:409562
		Ig strand C'	65..67	CDD:409562
		Ig strand D	75..78	CDD:409562
		Ig strand E	82..88	CDD:409562
		Ig strand F	95..102	CDD:409562
		Ig strand G	109..117	CDD:409562	2/7 (29%)
		Ig	122..206	CDD:472250	12/78 (15%)
		Ig strand B	138..142	CDD:409353	0/3 (0%)
		Ig strand C	151..155	CDD:409353	1/3 (33%)
		Ig strand E	173..177	CDD:409353
		Ig strand F	187..192	CDD:409353
		Ig strand G	201..204	CDD:409353
		Ig_3	228..296	CDD:464046
		CRD_FZ	325..467	CDD:470581
		PTKc_Musk	579..868	CDD:133181
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581