Protein Alignment MUSK and Nrk

DIOPT Version :10

• Sequence 1: XP_005252051.1
• Gene: MUSK / 4593
• HGNCID: 7525
• Length: 879
• Species: Homo sapiens
• Sequence 2: NP_477255.1
• Gene: Nrk / 36445
• FlyBaseID: FBgn0020391
• Length: 724
• Species: Drosophila melanogaster
• Alignment Length: 693
• Identity: 265/693 - (38%)
• Similarity: 346/693 - (49%)
• Gaps: 175/693 - (25%)

Human   320 QKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEA--QELLVHTAWNEL-KVVSPVCRPAAE 381
            :::..||||.|.|:||...|......    |..||...  .|.:....|:|| ..::.:||.|||
  Fly    63 EREENGYCAPYSGKVCKEYLTGQVWY----SLEDPTGGWKNEQVTTALWDELISDLTGLCREAAE 123

Human   382 ALLCNHIFQEC-SPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECS 445
            .:||.:.|..| ..|......|:|.|.|.|....||..:|:::|||..|.::........:|.||
  Fly   124 KMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCS 188

Human   446 KLPSMHWDPTACARLPHLDY-----------------------------NKENL----------- 470
            .||  |::  |..|.|:..|                             :|..:
  Fly   189 SLP--HYN--ASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPH 249

Human   471 KTF-PPMT---------------SSKP---------SV-----DIP-------------NLPSSS 492
            |.| ||:.               ..:|         ||     |||             |.|...
  Fly   250 KHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKM 314

Human   493 SSSFSVSPTYSMTVIISIMSSFAIFVL-LTITTLYCCRRRKQWK--------------------- 535
            ...|    |.||..:::.:...||..| |.|..:|...:.|.:.
  Fly   315 EKFF----TPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCG 375

Human   536 ---NKKRE------------------------SAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNP 573
               |..||                        |..|.|||:.:  :.|.....|         |.
  Fly   376 GNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTN--VSDAKGTKP---------NA 429

Human   574 KLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 638
            :|..|||||.:|.|||.:|:||||||||||||||:|.:...:|||||||::||..||.||:|||.
  Fly   430 RLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREAC 494

Human   639 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPG 703
            |:||||:||||:||||||:|:||||||||||.|||:||||:.||:........|   |.|::.
  Fly   495 LLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD---RLQLNE-- 554

Human   704 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKA 768
                  ...|.:|..:||||.||||||||||||||||||:.|:|.|||||||||..||..||||.
  Fly   555 ------LHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKG 613

Human   769 NENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSC 833
            :|||.|||||||.|||.||:::.||||||||:.|||:||:.||||:|:.|||||.|:::||:|.|
  Fly   614 DENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGC 678

Human   834 PENCPVELYNLMRLCWSKLPADRPSFTSI-----HRILERMCE 871
            |:|.|:.:|.|||.||::.|::||.|..|     |.|.|..|:
  Fly   679 PDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESECK 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	IgI_1_MuSK	28..117	CDD:409562
		Ig strand A	28..31	CDD:409562
		Ig strand A'	35..39	CDD:409562
		Ig strand B	45..52	CDD:409562
		Ig strand C	58..63	CDD:409562
		Ig strand C'	65..67	CDD:409562
		Ig strand D	75..78	CDD:409562
		Ig strand E	82..88	CDD:409562
		Ig strand F	95..102	CDD:409562
		Ig strand G	109..117	CDD:409562
		Ig	122..206	CDD:472250
		Ig strand B	138..142	CDD:409353
		Ig strand C	151..155	CDD:409353
		Ig strand E	173..177	CDD:409353
		Ig strand F	187..192	CDD:409353
		Ig strand G	201..204	CDD:409353
		Ig_3	228..296	CDD:464046
		CRD_FZ	325..467	CDD:470581	48/174 (28%)
		PTKc_Musk	579..868	CDD:133181	178/293 (61%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:470581	48/152 (32%)
		KR	217..299	CDD:214527	11/81 (14%)
		PTKc_Musk	435..713	CDD:133181	176/288 (61%)