back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUSK and CG3277

DIOPT Version :10

Sequence 1:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens
Sequence 2:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	198/818 - (24%)
Similarity:	328/818 - (40%)	Gaps:	215/818 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   191 VAKNSLGTAYSK------VVKLEVEEESEPEQ----------------DTKVFARILRAPESHNV 233
            :.:|::|.|..:      ::.|....|.||||                :.....|:...|:....
  Fly    19 LVRNAVGQAPRENATNPTLISLVRSSEKEPEQMESHRYVTGLSEPIAMEPLTRMRLNPNPDGEIT 83

Human   234 TFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTC--IATN 296
            ...:.|||:...  ||...:.|.:|   :..|:....:...|.:||            |  ...:
  Fly    84 ELTTNVTLYMEK--IPRLQVRWQDN---LPQGTSYNVLVSAVNNSR------------CPDAPCS 131

Human   297 KHGEKFSTAKAAATISIAEWSKPQKD------NKGYCAQYR--GEVCNAVLAKDALVFLNTSYAD 353
            ::|.|...| :|.|.|:.....|..:      |..:..||:  .|..||::.:.|.|::
  Fly   132 EYGIKEKNA-SAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVYI------ 189

Human   354 PEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKEL---- 414
                                |.|           :..:||..:.|||..:     |||.::
  Fly   190 --------------------PQC-----------LEGKCSCQLAPTPPKV-----LAVAKMLSNE 218

Human   415 -------FCAKEWLVMEEKT--HRGLYRSEMHLLSVPECSKLPSMHWD------PTACARLPHLD 464
                   ..|.|.|..|:.:  |..|...:|.|....|.:  ||:.|.      .|...:|..|:
  Fly   219 TISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETN--PSLPWGGVLKHLMTRVYKLSELN 281

Human   465 YNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPT-----YSMTVI----------------- 507
            : :...|.|..:........:....|.|..:..:.||     .|:|.:
  Fly   282 F-RATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSN 345

Human   508 -ISIMSSFAIFVLLT-ITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLL 570
             |.:||:..|.::|. :..|...|||.:...|.|:...:.:.|..:..:  .:..|..|.. ..:
  Fly   346 SIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAI--EMEDNVNYVD-KYV 407

Human   571 LNPKLLSL----EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA 631
            ...::|.|    |.|.:.|:..|.:||||||:|.:|.|..|......|:||||.||....||..|
  Fly   408 EKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVA 472

Human   632 DFQREAALMAEF-DNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSM-----------SPHT 684
            ::..|..::... .:.|:|..||.|.:..|..::.||:..|:|..:||::           :.:|
  Fly   473 EYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYT 537

Human   685 VC----------------SLSHSDLSMRAQ---------------VSSPGPPPLSCAEQLC---- 714
            .|                |:::.:|...:|               :..|.|   |.||...
  Fly   538 SCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHP---SFAETTYTIVE 599

Human   715 ----------------IARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 763
                            .|.|:|.||.:|.|::..|||||.||.|:..|..:||:||||||:
  Fly   600 DEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRH---- 660

Human   764 DYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG 828
            ..|.......:|:||:..|:|..|.|:::||:||||||||||.:.|..||..::::|:|.::..|
  Fly   661 GIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAG 725

Human   829 NILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL 866
            |.|..||.|..::|.:|..||.:.|.:||:|.:::::|
  Fly   726 NRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 763

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.