DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUSK and musk

DIOPT Version :9

Sequence 1:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens
Sequence 2:	NP_001004503.1	Gene:	musk / 334526	ZFINID:	ZDB-GENE-030131-6458	Length:	941	Species:	Danio rerio

Alignment Length:	945	Identity:	557/945 - (58%)
Similarity:	664/945 - (70%)	Gaps:	100/945 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     6 NIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKL 70
            |.|||  :.|..||.||.|.:||.|||.|||||:.::..|||:|.|:||||.:|.||||...|:.
Zfish     6 NTPLV--VFLAFFSLTEGLQRAPRITTLLETVDSSLDHNATFICEVDSYPQADIIWTRNNYPIRY 68

Human    71 FDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEG 135
            :|:||.|:||||:|.|.:|:|||.|.|||.||||||.| :||||||:||||:|.|.|.|:.:|..
Zfish    69 YDSRYVIQENGQMLIIPNVKDSDSGEYCCIANNGVGEA-KSCGALQLKMKPQIKRHPTNMTLILE 132

Human   136 LKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAY 200
            .||||||.::|.|||.:||||.|..::.|:|||:||||||:|.|::|||||||||||:||.|.|:
Zfish   133 SKAVLPCLSLGYPKPEISWIKEDDLIKANNRIAILESGSLKITNIKKEDAGQYRCVARNSFGIAF 197

Human   201 SKVVKLEVEEESEPEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSG 265
            |:.|.:||:..          |:||:.|:...|..||.|||.|.|||.|:|:|||:||||.:|..
Zfish   198 SRPVTIEVQAP----------AKILKVPKEKRVQIGSEVTLECNATGNPIPSITWLENGNTISGA 252

Human   266 SIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQY 330
            |:.|::...||.|.||:.:.||.||||.|||:|....:|.||.|.|:::|| :..|.:.|||:.|
Zfish   253 SVVETLVGEVILSVLQVVVHKPALYTCQATNRHSGGENTVKATAKITVSEW-RLYKGHAGYCSTY 316

Human   331 RGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSP- 394
            ||:||..||.:|||||.|.|..:||:|||.|..:||.||..||..|||||.:|||:..||:|:|
Zfish   317 RGDVCRNVLRRDALVFFNYSLPNPEDAQEYLAQSAWPELDGVSSFCRPAARSLLCHSTFQDCNPS 381

Human   395 GVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACAR 459
            |:.|.|.|:|||:||.||||:|.|||...||::.||...     :::|||:.|||...||::|..
Zfish   382 GLGPAPKPVCREHCLTVKELYCYKEWRSAEERSQRGFQH-----ITLPECTSLPSQQADPSSCTA 441

Human   460 LPHLDYNKENLK-------------TFPPMTSSKP--------------SVDI------------ 485
            :|::|..|:.:.             |.....||.|              |||:
Zfish   442 VPYVDIKKDQVTSTCYNDKGRFYQGTHNVTASSIPCQRWNQQDPHQHRLSVDVIPELRNAENYCR 506

Human   486 ---------------PNL-------------------PSSSSSSF-----SVSPTYSMTVIISIM 511
                           ||:                   ||.:..:.     |||..|||:|||.::
Zfish   507 NPGGESDRPWCYTTNPNVRWEYCLVPKCGEVISIRTAPSITKPAHFYPPPSVSTAYSMSVIIFVI 571

Human   512 SSFAIFVLLTITTLYCCRRRKQWKNKK-RESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKL 575
            :.||.....|:..|.|.||:|.||.:| |.....||||||||||||||||||||||:|||||.||
Zfish   572 AGFAGAAFFTVLILMCHRRKKMWKKRKSRVLETPTLTTLPSELLLDRLHPNPMYQRLPLLLNSKL 636

Human   576 LSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALM 640
            ||||||||||||||||||||||||||||||||||.||||||||||||||||.|||.|||||||||
Zfish   637 LSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPTEPFTMVAVKMLKEEASTDMQNDFQREAALM 701

Human   641 AEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP- 704
            :|||:||||:|||||||||||||:||||||||||||||........|||...|:..:.||.|..
Zfish   702 SEFDHPNIVRLLGVCAVGKPMCLMFEYMAYGDLNEFLRRRCATQQPSLSRDTLTSSSLVSEPERY 766

Human   705 PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKAN 769
            |||||.|||.|::||||||||||||||||||||||||||.||:||||||||||||||:||||||:
Zfish   767 PPLSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAENLVVKIADFGLSRNIYAADYYKAS 831

Human   770 ENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCP 834
            |||||||||||||||||||||:||||||||||||||||||:|||||||||||||||||||:||||
Zfish   832 ENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNVLSCP 896

Human   835 ENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 869
            ||||.|||||||||||..|.|||||.|||||||||
Zfish   897 ENCPQELYNLMRLCWSGHPTDRPSFASIHRILERM 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	I-set	28..117	CDD:254352	54/88 (61%)
		Ig	36..117	CDD:299845	48/80 (60%)
		I-set	121..203	CDD:254352	49/81 (60%)
		Ig	135..201	CDD:299845	42/65 (65%)
		I-set	223..306	CDD:254352	41/82 (50%)
		Ig	239..306	CDD:143165	35/66 (53%)
		CRD_FZ	325..467	CDD:295308	73/142 (51%)
		PTKc_Musk	579..868	CDD:133181	246/289 (85%)
		Pkinase_Tyr	585..866	CDD:285015	238/281 (85%)
musk	NP_001004503.1	I-set	26..108	CDD:254352	49/82 (60%)
		Ig	37..108	CDD:299845	40/71 (56%)
		IG_like	124..205	CDD:214653	47/80 (59%)
		Ig	136..198	CDD:299845	40/61 (66%)
		I-set	210..298	CDD:254352	44/87 (51%)
		Ig	212..300	CDD:299845	44/87 (51%)
		CRD_TK_ROR_related	309..449	CDD:143578	73/144 (51%)
		KR	454..536	CDD:214527	9/81 (11%)
		PTKc_Musk	640..930	CDD:133181	246/289 (85%)
		Pkinase_Tyr	646..928	CDD:285015	238/281 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	488	1.000	Domainoid score	I2947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4084
Inparanoid	1	1.050	991	1.000	Inparanoid score	I2367
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40228
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0008235
OrthoInspector	1	1.000	-	-		oto45781
orthoMCL	1	0.900	-	-		OOG6_110114
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.480