DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUSK and egl-15

DIOPT Version :9

Sequence 1:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	239/1001 - (23%)
Similarity:	392/1001 - (39%)	Gaps:	236/1001 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    22 EKLPKAPVITTPLETVDALVEEVATFMC-AVESYPQPEISWTRNKILIK--LFDTRYSIRE--NG 81
            |.:|:...:..  |..:..:.:...|.| ...|.....:.|.||..|:|  ..| :..||:  |.
Worm    30 ENIPRFKHVAN--ERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQID-KDKIRKDNNR 91

Human    82 QLLTILSVEDSDDGIYCCTANNGVG--------GAVESCG--------ALQVKMK--------PK 122
            .:|.:.:::.||.|::.|..:|..|        ..::.|.        .|.:.|:        .:
Worm    92 MMLHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKE 156

Human   123 ITRPPINVKIIEGLKA----------------VLPC---------TT-------MGNPK--PSVS 153
            ..|..:|...:.|...                ::||         ||       .|.|:  |.|.
Worm   157 AKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVK 221

Human   154 WI--KGDS---PLREN------SRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLE 207
            .:  |.|.   |:.::      ||...:.:........::||....:.||.:      :.:.:|.
Worm   222 RVVLKKDDVIVPVHDSEESPSESRTEFINADEKENKEDEEEDYSVSQPVAPD------AGLTELN 280

Human   208 VEEESEPEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQE--- 269
            :..|..|.  .|....|:...|:|.:..|..:.|:|.|.|.|.|.|.|.:||..:...|.:.
Worm   281 ITAEEPPY--FKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGY 343

Human   270 ---------SVKDRVI-DSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNK 324
                     .|:|.|: ||         |.:.|.|.||.|   |..|....|.:....:|.
Worm   344 EFKFNRWSLEVEDAVVADS---------GEFHCEALNKVG---SAKKYFHVIIVNRMRRPP---- 392

Human   325 GYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAW---NELKVVSPVCRPAAEALLCN 386
                    .:...:||..::...:|:....:...:||.|..|   |::.........:||..:.|
Worm   393 --------IIVPNILANQSVNINDTATFHCKVVSDLLPHIIWVRINKINGSYSYYNNSAEEYMFN 449

Human   387 -------------HIFQECSPGVVPTPIPICREY-CLAVKEL--FCAKEWLVMEEKTHRGLYRSE 435
                         |:..|.:..:....:.....| ||:...|  ..|...|.:.|       ...
Worm   450 YTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNE-------FMA 507

Human   436 MHLLSVPECSKLPSM-HWDPT-----------------------ACARLPHLDYNKENLKTFPPM 476
            :|||:..|    |.: .|..:                       .|.:..|   .|..:.....:
Worm   508 IHLLTGDE----PKIDRWTTSDYIFTTILLFLLLAATLFGILFMVCKQTLH---KKGFMDDTVGL 565

Human   477 TSSKPSVDIPNLP---SSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKK 538
            .:.|..|.:...|   .:.:|....|| |.:.:|.:           .||.....|::::..|.:
Worm   566 VARKKRVVVSKRPMNEDNENSDDEPSP-YQIQIIET-----------PITKKEAARKQRKRMNSE 618

Human   539 RESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQAR 603
                    .|:.||..:|   .:|::              |..|:.:..|..:||||||.|::|.
Worm   619 --------NTVLSEYEVD---SDPVW--------------EVERSKLSLVHMLGEGAFGEVWKAT 658

Human   604 APGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF----DNPNIVKLLGVCAVGKPMCLL 664
            .......|  ..||||.||..|......|...|   |..|    ::.|:::|:|.|....|:.::
Worm   659 YKETENNE--IAVAVKKLKMSAHEKELIDLVSE---METFKVIGEHENVLRLIGCCTGAGPLYVV 718

Human   665 FEYMAYGDLNEFLRSMSP-HTVCSLSHSDLS--MRAQVSSPGP-----PPLSCAEQLCIARQVAA 721
            .|...:|:|.:|||:..| ......|..:|:  :..:.:|...     |.|:....:..|.|||.
Worm   719 VELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQ 783

Human   722 GMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFY 786
            ||.:|:.:|.:|||||.||.|||:..|:||:||||||:::..|||:...|..:||:||..|::..
Worm   784 GMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDS 848

Human   787 NRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSK 851
            |.||.|||||:|||:||||.:.|..||..:|..|:...:::|..:..|..||.|:|:||..||.:
Worm   849 NVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWRE 913

Human   852 LPADRPSFTSIHRILERMCERAEGTV 877
            ...:||||.:|...|:.|......|:
Worm   914 KLEERPSFKTIVDYLDWMLTMTNETI 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	I-set	28..117	CDD:254352	22/109 (20%)
		Ig	36..117	CDD:299845	21/101 (21%)
		I-set	121..203	CDD:254352	20/126 (16%)
		Ig	135..201	CDD:299845	18/110 (16%)
		I-set	223..306	CDD:254352	27/95 (28%)
		Ig	239..306	CDD:143165	23/79 (29%)
		CRD_FZ	325..467	CDD:295308	28/184 (15%)
		PTKc_Musk	579..868	CDD:133181	112/300 (37%)
		Pkinase_Tyr	585..866	CDD:285015	109/292 (37%)
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653	20/85 (24%)
		Ig	47..126	CDD:299845	19/79 (24%)
		Ig	302..382	CDD:299845	26/91 (29%)
		IG_like	306..384	CDD:214653	25/89 (28%)
		IG_like	401..502	CDD:214653	17/100 (17%)
		Ig3_FGFR	407..503	CDD:143175	17/95 (18%)
		PKc_like	627..933	CDD:304357	115/327 (35%)
		Pkinase_Tyr	640..928	CDD:285015	109/292 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910