DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUSK and lin-18

DIOPT Version :9

Sequence 1:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens
Sequence 2:	NP_508684.4	Gene:	lin-18 / 180679	WormBaseID:	WBGene00003007	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	118/411 - (28%)
Similarity:	182/411 - (44%)	Gaps:	81/411 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   506 VIISIMSSFAIFVLLTITTLYCCRRRKQWKNKK------------RESAAVTLTTLPSELLLDRL 558
            |||.|.   |.|:|:...||.|..:|    :||            |.|...|.:..|..|...|.
Worm   177 VIICIA---AAFLLIVAATLICYFKR----SKKEDMIPTRLPTSFRNSLKSTKSAQPFLLSTPRD 234

Human   559 HP------------------NPMYQRMPLLLNPK--LLSLEYPRNNIEYVRDIGEGAFGRVFQA- 602
            .|                  |.:....|..::.:  ||.|...|:..:.:....||.||.|..|
Worm   235 GPPTLSAISSAPCSSSSASGNSIIPSKPRNIDVRRALLQLYQDRDAFQSLPLDMEGTFGEVRYAI 299

Human   603 ------RAPGLLPYEPFTM-----VAVKMLKEEASADMQADFQREAALMAEF-DNPNIVKLLGVC 655
                  ...|.:..|..|.     |..|.||..||......|..:|.|.... .:.|:.::..|.
Worm   300 WRQVDDVLNGDVDDEEDTFCNQEAVYTKTLKNNASPIQLDRFLSDALLFYNITPHQNLSQVACVA 364

Human   656 AVGK----------PMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCA 710
            :.|:          |: :.:.:..:|:|.:||      |:|  .|.|.:..||.       |...
Worm   365 SFGRFDRPETVTDFPL-VCYRHQGFGNLKKFL------TIC--RHGDKTKGAQT-------LRTH 413

Human   711 EQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE---NMVVKIADFGLSRNIYSADYYKANEND 772
            :.:.:|.||::.:|::.:.:.||.|:|.||||:.|   .:.|::.|..|||:::.|||:...:|:
Worm   414 QLVSLATQVSSAVAHIHKYRIVHNDIAARNCLIAEVNGRLQVQLCDSALSRDLFPADYHCLGDNE 478

Human   773 AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENC 837
            ..|::||.||:|....|::.:|||:.||:|||:.|.|..|:..:..|||...:..|..|..|.||
Worm   479 NRPLKWMSPEAIANELYSSAADVWSLGVLLWELMSLGGSPHAEIDPEEVYTMILKGKRLQQPNNC 543

Human   838 PVELYNLMRLCWSKLPADRPS 858
            |.:||.:|..||..|..||||
Worm   544 PDQLYEVMLCCWRVLSEDRPS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	I-set	28..117	CDD:254352
		Ig	36..117	CDD:299845
		I-set	121..203	CDD:254352
		Ig	135..201	CDD:299845
		I-set	223..306	CDD:254352
		Ig	239..306	CDD:143165
		CRD_FZ	325..467	CDD:295308
		PTKc_Musk	579..868	CDD:133181	93/306 (30%)
		Pkinase_Tyr	585..866	CDD:285015	92/300 (31%)
lin-18	NP_508684.4	WIF	19..149	CDD:128745
		PTK_Ryk	274..579	CDD:270639	94/307 (31%)
		Pkinase_Tyr	289..572	CDD:285015	92/292 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910