DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUSK and kin-30

DIOPT Version :9

Sequence 1:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens
Sequence 2:	NP_506771.3	Gene:	kin-30 / 180032	WormBaseID:	WBGene00002211	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	119/403 - (29%)
Similarity:	192/403 - (47%)	Gaps:	55/403 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   506 VIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESA------------AVTLTTLPSELLLDR- 557
            :|:.:|.:..|:.:|:|..:..|..|:.:::...::.            |...|...|.|.:|:
Worm    28 IIVFLMCALFIYGVLSIIFVTICFLRRIYRSSATKNGNRRYLVQNTYVKAQLDTNSSSSLPVDKE 92

Human   558 -LHPNPMYQRMPLL-----LNPKLLSLEY-PRNNIE------YVRDIGEGAFGRVFQARAPGLLP 609
             :....:.:..|::     ||.:...|.| |...|.      :.:..|:|.||:|.:|    ||.
Worm    93 IIETISINEETPIITDYQPLNERAEYLPYNPAFEIHSEHLDVFEKQFGQGNFGKVNKA----LLK 153

Human   610 Y------EPFTM-VAVKMLKEEASADMQAD--FQREAALMAEF-DNPNIVKLLGVC-----AVGK 659
            .      |...| ||||  |...|.|...|  ...|..||... .:||::.::|..     .:|:
Worm   154 LINQKTGEVVRMDVAVK--KPADSTDKSQDKLILDEIKLMCAIGKHPNVLAIVGAITKQEKVIGR 216

Human   660 PMCLLF-EYMAYGDLNEFLRSMSPHTV-CSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAG 722
            ...|:. |::..|||...|: .:|:|. ..|:.:|.:....|:|.....||.::....|.|:|.|
Worm   217 EHNLVVTEFVEGGDLRSVLK-YTPYTFHDELTSTDRTGGQMVNSDIFDELSTSDLYSFAYQIANG 280

Human   723 MAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYK--ANENDAIPIRWMPPESIF 785
            |.||:.:..||||||.||..|..|.:::|.||||:|:.....||:  .|.:..:||.|:.||...
Worm   281 MEYLAAKPCVHRDLALRNVFVKRNKMIRIGDFGLARHHSKKSYYRMQCNPDTPLPIFWLAPECFN 345

Human   786 YNRYTTESDVWAYGVVLWEIFSYGLQPY---YGMAHEEVIYYVRDGNILSCPENCPVELYNLMRL 847
            .:::|..:|||:|||.|:|:||.|..||   :.....:|::|::.|..||.|..|..|:|..|..
Worm   346 ESKFTEMTDVWSYGVCLFELFSLGESPYKKLHNSPSYDVVHYLKKGYRLSAPRYCNAEIYEFMLY 410

Human   848 CWSKLPADRPSFT 860
            ||:.....||.||
Worm   411 CWNIDATLRPKFT 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	I-set	28..117	CDD:254352
		Ig	36..117	CDD:299845
		I-set	121..203	CDD:254352
		Ig	135..201	CDD:299845
		I-set	223..306	CDD:254352
		Ig	239..306	CDD:143165
		CRD_FZ	325..467	CDD:295308
		PTKc_Musk	579..868	CDD:133181	103/311 (33%)
		Pkinase_Tyr	585..866	CDD:285015	101/304 (33%)
kin-30	NP_506771.3	TyrKc	134..428	CDD:197581	100/297 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910